Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults-Reference-Cited by-同舟云学术

Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults

Published:2022-11-01 Issue:11 Volume:79 Page:1165
ISSN:2168-6149
Container-title:JAMA Neurology
language:en
Short-container-title:JAMA Neurol

Author:

Chételat Gael¹,Lutz Antoine²,Klimecki Olga³,Frison Eric⁴,Asselineau Julien⁴,Schlosser Marco⁵⁶,Arenaza-Urquijo Eider M.¹⁷,Mézenge Florence¹,Kuhn Elizabeth¹,Moulinet Inès¹,Touron Edelweiss¹,Dautricourt Sophie¹,André Claire¹,Palix Cassandre¹,Ourry Valentin¹,Felisatti Francesca¹,Gonneaud Julie¹,Landeau Brigitte¹,Rauchs Géraldine¹,Chocat Anne¹,Quillard Anne¹,Devouge Eglantine Ferrand¹⁸⁹,Vuilleumier Patrik³,de La Sayette Vincent¹⁰,Vivien Denis¹¹¹,Collette Fabienne¹²,Poisnel Géraldine¹,Marchant Natalie L.⁵,ALLAIS Florence¹³,ANDRÉ Claire¹³,ARENAZA URQUIJO Eider M¹³,ASSELINEAU Julien¹³,BAEZ LUGO Sebastian¹³,BATCHELOR Martine¹³,BEAUGONIN Axel¹³,BEJANIN Alexandre¹³,CHAMPETIER Pierre¹³,CHÉTELAT Gaël¹³,CHOCAT Anne¹³,COLLETTE Fabienne¹³,COUERON Roxane¹³,DAUTRICOURT Sophie¹³,DE FLORES Robin¹³,DE LA SAYETTE Vincent¹³,DELAMILLIEURE Pascal¹³,DELARUE Marion¹³,DEZA ARAUJO Yacila¹³,FELISATTI Francesca¹³,FERRAND DEVOUGE Eglantine¹³,FRISON Eric¹³,GARNIER CRUSSARD Antoine¹³,GHEYSEN Francis¹³,GONNEAUD Julie¹³,HEIDMANN Marc¹³,HUONG TRAN (DOLMA) Thien (Titi)¹³,JESSEN Frank¹³,KLIMECKI Olga¹³,KROLAK SALMON Pierre¹³,KUHN Elizabeth¹³,LANDEAU Brigitte¹³,LE DU Gwendoline¹³,LEFRANC Valérie¹³,LUTZ Antoine¹³,MARCHANT Natalie¹³,MEZENGE Florence¹³,MOLINUEVO Jose Luis¹³,MOULINET Inès¹³,OURRY Valentin¹³,PALIX Cassandre¹³,PALY Léo¹³,POISNEL Géraldine¹³,POLETTI Stefano¹³,QUILLARD Anne¹³,RAUCHS Géraldine¹³,REHEL Stéphane¹³,REQUIER Florence¹³,SALMON Eric¹³,SANCHEZ Raquel¹³,SCHIMMER Corinne¹³,SCHLOSSER Marco¹³,SCHWIMMER Christine¹³,SHERIF Siya¹³,TOURON Edelweiss¹³,VANHOUTTE Matthieu¹³,VIVIEN Denis¹³,VUILLEUMIER Patrik¹³,WALLET Cédrick¹³,WARE Caitlin¹³,WIRTH Miranka¹³,

Affiliation:

1. Normandie Univ, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain @ Caen-Normandie, Cyceron, France

2. Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon 1 University, Lyon, France

3. Swiss Center for Affective Sciences, Department of Neuroscience, University of Geneva Medical School, Geneva, Switzerland

4. EUCLID/F-CRIN Clinical Trials Platform, INSERM, CHU Bordeaux, University of Bordeaux, CIC1401-EC, Bordeaux, France

5. Division of Psychiatry, University College London, London, United Kingdom

6. Department of Psychology, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland

7. Barcelonabeta Brain Research Center, Fundación Pasqual Maragall, Barcelona, Spain

8. Normandie Univ, UNIROUEN, Department of General Practice, Rouen, France

9. Rouen University Hospital, CIC-CRB 1404, F 76000, Rouen, France

10. CHU Caen-Normandie, Department of Neurology, Caen, France

11. CHU Caen-Normandie, Department of Clinical Research, Caen, France

12. GIGA-CRC, In Vivo Imaging, Université de Liège and Belgian National Fund for Scientific Research, Liège, Belgium

13. for the Medit-Ageing Research Group

Abstract

ImportanceNo lifestyle-based randomized clinical trial directly targets psychoaffective risk factors of dementia. Meditation practices recently emerged as a promising mental training exercise to foster brain health and reduce dementia risk.ObjectiveTo investigate the effects of meditation training on brain integrity in older adults.Design, Setting, and ParticipantsAge-Well was a randomized, controlled superiority trial with blinded end point assessment. Community-dwelling cognitively unimpaired adults 65 years and older were enrolled between November 24, 2016, and March 5, 2018, in France. Participants were randomly assigned (1:1:1) to (1) an 18-month meditation-based training, (2) a structurally matched non-native language (English) training, or (3) no intervention arm. Analysis took place between December 2020 and October 2021.InterventionsMeditation and non-native language training included 2-hour weekly group sessions, practice of 20 minutes or longer daily at home, and 1-day intensive practices.Main Outcomes and MeasuresPrimary outcomes included volume and perfusion of anterior cingulate cortex (ACC) and insula. Main secondary outcomes included a global composite score capturing metacognitive, prosocial, and self-regulatory capacities and constituent subscores.ResultsAmong 137 participants (mean [SD] age, 69.4 [3.8] years; 83 [60.6%] female; 54 [39.4%] male) assigned to the meditation (n = 45), non-native language training (n = 46), or no intervention (n = 46) groups, all but 1 completed the trial. There were no differences in volume changes of ACC (0.01 [98.75% CI, −0.02 to 0.05]; P = .36) or insula (0.01 [98.75% CI, −0.02 to 0.03]; P = .58) between meditation and no intervention or non-native language training groups, respectively. Differences in perfusion changes did not reach statistical significance for meditation compared with no intervention in ACC (0.02 [98.75% CI, −0.01 to 0.05]; P = .06) or compared with non-native language training in insula (0.02 [98.75% CI, −0.01 to 0.05]; P = .09). Meditation was superior to non-native language training on 18-month changes in a global composite score capturing attention regulation, socioemotional, and self-knowledge capacities (Cohen d, 0.52 [95% CI, 0.19-0.85]; P = .002).Conclusions and RelevanceThe study findings confirm the feasibility of meditation and non-native language training in elderly individuals, with high adherence and very low attrition. Findings also show positive behavioral effects of meditation that were not reflected on volume, and not significantly on perfusion, of target brain areas.Trial RegistrationClinicalTrials.gov Identifier: NCT02977819

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

Link

https://jamanetwork.com/journals/jamaneurology/articlepdf/2796818/jamaneurology_chtelat_2022_oi_220060_1667929362.95586.pdf

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