Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis

Author:

Cagol Alessandro12,Schaedelin Sabine3,Barakovic Muhamed12,Benkert Pascal3,Todea Ramona-Alexandra124,Rahmanzadeh Reza12,Galbusera Riccardo12,Lu Po-Jui12,Weigel Matthias125,Melie-Garcia Lester12,Ruberte Esther126,Siebenborn Nina12,Battaglini Marco7,Radue Ernst-Wilhelm1,Yaldizli Özgür12,Oechtering Johanna2,Sinnecker Tim126,Lorscheider Johannes2,Fischer-Barnicol Bettina2,Müller Stefanie8,Achtnichts Lutz9,Vehoff Jochen8,Disanto Giulio10,Findling Oliver9,Chan Andrew11,Salmen Anke11,Pot Caroline12,Bridel Claire13,Zecca Chiara1014,Derfuss Tobias2,Lieb Johanna M.4,Remonda Luca15,Wagner Franca16,Vargas Maria I.17,Du Pasquier Renaud1218,Lalive Patrice H.13,Pravatà Emanuele1019,Weber Johannes20,Cattin Philippe C.21,Gobbi Claudio1014,Leppert David2,Kappos Ludwig12,Kuhle Jens2,Granziera Cristina12

Affiliation:

1. Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel, University of Basel, Basel, Switzerland

2. Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland

3. Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland

4. Division of Diagnostic and Interventional Neuroradiology, Clinic for Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland

5. Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland

6. Medical Image Analysis Center (MIAC) and Quantitative Biomedical Imaging Group, Department of Biomedical Engineering, University of Basel, Basel, Switzerland

7. Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy

8. Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

9. Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland

10. Neurology Department, Neurocenter of Southern Switzerland, Lugano, Switzerland

11. Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

12. Division of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland

13. Division of Neurology, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland

14. Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

15. Department of Radiology, Cantonal Hospital Aarau, Aarau, Switzerland

16. Department of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

17. Department of Radiology, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland

18. Division of Radiology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland

19. Department of Neuroradiology, Neurocenter of Southern Switzerland, Lugano, Switzerland

20. Department of Radiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

21. Center for Medical Image, Analysis, and Navigation, Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

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