APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome—Implications for Clinical Trials and Treatments for All-Reference-Cited by-同舟云学术

APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome—Implications for Clinical Trials and Treatments for All

Published:2021-08-01 Issue:8 Volume:78 Page:913
ISSN:2168-6149
Container-title:JAMA Neurology
language:en
Short-container-title:JAMA Neurol

Author:

Lemere Cynthia A.¹,Head Elizabeth²,Holtzman David M.³

Affiliation:

1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

2. Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine

3. Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St Louis, Missouri

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

Link

https://jamanetwork.com/journals/jamaneurology/articlepdf/2781527/jamaneurology_lemere_2021_ed_210011_1628705039.98841.pdf

Reference15 articles.

1. Dementia in Down syndrome: unique insights for Alzheimer disease research.;Lott;Nat Rev Neurol,2019

2. Alzheimer’s disease in adults with Down syndrome.;Zigman;Int Rev Res Ment Retard,2008

3. Alzheimer disease: an update on pathobiology and treatment strategies.;Long;Cell,2019

4. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).;Hyman;Proc Natl Acad Sci U S A,1995

5. Onset of dementia is associated with apolipoprotein E epsilon4 in Down’s syndrome.;Schupf;Ann Neurol,1996

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