Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome-Reference-Cited by-同舟云学术

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Published:2021-08-01 Issue:8 Volume:78 Page:937
ISSN:2168-6149
Container-title:JAMA Neurology
language:en
Short-container-title:JAMA Neurol

Author:

Bejanin Alexandre¹²,Iulita Maria Florencia¹²,Vilaplana Eduard¹²,Carmona-Iragui Maria¹²³,Benejam Bessy³,Videla Laura¹²³,Barroeta Isabel¹²,Fernandez Susana¹,Altuna Miren¹²,Pegueroles Jordi¹²,Montal Victor¹²,Valldeneu Silvia¹²,Giménez Sandra⁴,González-Ortiz Sofía⁵,Muñoz Laia¹²,Padilla Concepción¹²,Aranha Mateus Rozalem¹²,Estellés Teresa¹²,Illán-Gala Ignacio¹²,Belbin Olivia¹²,Camacho Valle⁶,Wilson Liam Reese⁷,Annus Tiina⁷,Osorio Ricardo S.⁸,Videla Sebastián⁹,Lehmann Sylvain¹⁰,Holland Anthony J.⁷,Zetterberg Henrik¹¹¹²¹³¹⁴,Blennow Kaj¹¹¹²,Alcolea Daniel¹²,Clarimon Jordi¹²,Zaman Shahid H.⁷¹⁵,Blesa Rafael¹²,Lleó Alberto¹²,Fortea Juan¹²³

Affiliation:

1. Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

2. Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain

3. Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain

4. Multidisciplinary Sleep Unit, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

5. Hospital del Mar, Barcelona, Spain

6. Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

7. Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Douglas House, Cambridge, United Kingdom

8. Healthy Brain Aging and Sleep Center, Department of Psychiatry, New York University Grossman School of Medicine, New York

9. Clinical Research Support Unit, Bellvitge Biomedical Research Institute Department of Clinical Pharmacology, University of Barcelona, Barcelona, Spain

10. Le Laboratoire de Biochimie et Protéomique Clinique, Université Montpellier, Centre Hospitalier Universitaire Montpellier, Institut National de la Santé et de la Recherche Médicale, Montpellier, France

11. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mönldal, Sweden

12. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

13. UK Dementia Research Institute at University College London (UCL), London, United Kingdom

14. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom

15. Cambridgeshire and Peterborough National Health Service (NHS) Foundation Trust, Fulbourn Hospital, Elizabeth House, Cambridge, United Kingdom

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

Link

https://jamanetwork.com/journals/jamaneurology/articlepdf/2781524/jamaneurology_bejanin_2021_oi_210031_1628705003.15182.pdf

Reference48 articles.

1. Association of dementia with mortality among adults with Down syndrome older than 35 years.;Hithersay;JAMA Neurol,2019

2. Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study.;Fortea;Lancet,2020

3. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families.;Corder;Science,1993

4. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.;Strittmatter;Proc Natl Acad Sci U S A,1993

5. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.;Morris;Ann Neurol,2010

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