Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers

Author:

Brum Wagner S.12,Docherty Kieran F.3,Ashton Nicholas J.1456,Zetterberg Henrik178910,Hansson Oskar1011,McMurray John J. V.3,Blennow Kaj17

Affiliation:

1. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

2. Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

3. British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

4. King’s College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, United Kingdom

5. National Institute for Health and Care Research Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, United Kingdom

6. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway

7. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

8. Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, United Kingdom

9. UK Dementia Research Institute, University College London, London, United Kingdom

10. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China

11. Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden

Abstract

This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease.

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

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