Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients-Reference-Cited by-同舟云学术

Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients

Published:2023-06-01 Issue:6 Volume:80 Page:548
ISSN:2168-6149
Container-title:JAMA Neurology
language:en
Short-container-title:JAMA Neurol

Author:

Altomare Daniele¹²³,Barkhof Frederik⁴⁵,Caprioglio Camilla¹²,Collij Lyduine E.⁴,Scheltens Philip⁶,Lopes Alves Isadora⁴,Bouwman Femke⁶,Berkhof Johannes⁷,van Maurik Ingrid S.⁶⁷,Garibotto Valentina⁸⁹,Moro Christian¹²,Delrieu Julien¹⁰¹¹,Payoux Pierre¹²¹³,Saint-Aubert Laure¹²¹³,Hitzel Anne¹²,Molinuevo José Luis¹⁴¹⁵,Grau-Rivera Oriol¹⁴¹⁶¹⁷,Gispert Juan Domingo¹⁴¹⁶¹⁸,Drzezga Alexander¹⁹²⁰²¹,Jessen Frank²⁰²²²³,Zeyen Philip²²,Nordberg Agneta²⁴²⁵,Savitcheva Irina²⁶,Jelic Vesna²⁷,Walker Zuzana²⁸²⁹,Edison Paul³⁰,Demonet Jean-François³¹,Gismondi Rossella³²,Farrar Gill³³,Stephens Andrew W.³²,Frisoni Giovanni B.¹²,Abdelnour Carla³⁴,Aguilera Nuria³⁴,Aksman Leon³⁴,Alarcón-Martín Emilio³⁴,Alegret Montse³⁴,Alonso-Lana Silvia³⁴,Altomare Daniele³⁴,Andersen Pia³⁴,Arab Majd³⁴,Aspö Malin³⁴,Bader Ilona³⁴,Bader Ilse³⁴,Banton Nigel³⁴,Barkhof Frederik³⁴,Barnes Rodrigo³⁴,Barrie Dawn³⁴,Battle Mark³⁴,Belén Collado Ana³⁴,Bellet Julie³⁴,Berkhof Johannes³⁴,Biger Marine³⁴,Birck Cindy³⁴,Bischof Gerard³⁴,Boada Mercè³⁴,Boellaard Ronald³⁴,Bogdanovic Nenad³⁴,Bollack Ariane³⁴,Bombois Stéphanie³⁴,Borg Stefan³⁴,Borjesson-Hanson Anne³⁴,Boskov Vladimir³⁴,Boutantin Justine³⁴,Boutoleau-Bretonniere Claire³⁴,Bouwman Femke³⁴,Breuilh Laetitia³⁴,Bringman Eva³⁴,Brunel Baptiste³⁴,Bucci Marco³⁴,Buckley Chris³⁴,Buendía Mar³⁴,Bullich Santi³⁴,Calvet Anna³⁴,Cañada Laia³⁴,Cañada Marta³⁴,Caprioglio Camilla³⁴,Cardoso Jorge³⁴,Carlier Jasmine³⁴,Carre Elise³⁴,Carrie Isabelle³⁴,Cassagnaud Pascaline³⁴,Cassol Emmanuelle³⁴,Castilla-Martí Miguel³⁴,Cazalon Elodie³⁴,Chaarriau Tiphaine³⁴,Chaigeau Rachel³⁴,Chalmers Taylor³⁴,Clerc Marie-Thérèse³⁴,Clerigue Montserrat³⁴,Cognat Emmanuel³⁴,Coll Nina³⁴,Collij Lyduine E.³⁴,Connely Peter³⁴,Cordier Elodie³⁴,Costes Corine³⁴,Coulange Camille³⁴,Courtemanche Hélène³⁴,Creisson Eric³⁴,Crinquette Charlotte³⁴,Cuevas Rosario³⁴,Cufi Marie-Noëlle³⁴,Dardenne Sophie³⁴,de Arriba Maria³⁴,de Costa Luis Casper³⁴,de Gier Yvonne³⁴,de Verbizier Lonjon Delphine³⁴,Dekker Veronique³⁴,Dekyndt Bérengère³⁴,Delbeuck Xavier³⁴,Delrieu Julien³⁴,Demonet Jean-François³⁴,Deramecourt Vincent³⁴,Desclaux Françoise³⁴,Diaz Carlos³⁴,Diego Susana³⁴,Djafar Mehdi³⁴,Dölle Britta³⁴,Doull Laura³⁴,Dricot Laurence³⁴,Drzezga Alexander³⁴,Dubois Bruno³⁴,Dumont Julien³⁴,Dumur Jean³⁴,Dumurgier Julien³⁴,Dvorak Martin³⁴,Ecay Mirian³⁴,Edison Paul³⁴,Escher Claus³⁴,Estanga Ainara³⁴,Esteban Ester³⁴,Fanjaud Guy³⁴,Farrar Gill³⁴,Fauria Karine³⁴,Felez Sanchez Marta³⁴,Feukam Talla Patrick³⁴,Ford Lisa³⁴,Frisoni Giovanni B.³⁴,Fuster David³⁴,Gabelle Audrey³⁴,Garibotto Valentina³⁴,Gaubert Sinead³⁴,Gauci Cédric³⁴,Geldhof Christine³⁴,Georges Jean³⁴,Ghika Joseph³⁴,Gismondi Rossella³⁴,Gispert Juan Domingo³⁴,González Elena³⁴,Goovaerts Valerie³⁴,Goulart Denis Mariano³⁴,Grasselli Caroline³⁴,Grau-Rivera Oriol³⁴,Gray Katherine³⁴,Greensmith Martin³⁴,Grozn Laure³⁴,Guillemaud Céline³⁴,Gunn Fiona³⁴,Guntur Ramkumar Prasad³⁴,Hagman Göran³⁴,Hansseuw Bernard³⁴,Heeman Fiona³⁴,Hendriks Janine³⁴,Himmelmann Jakob³⁴,Hitzel Anne³⁴,Hives Florent³⁴,Hoenig Merle³⁴,Hourrègue Claire³⁴,Hudson Justine³⁴,Huguet Jordi³⁴,Ibarria Marta³⁴,Iidow Ifrah³⁴,Indart Sandrine³⁴,Ingala Silvia³⁴,Ivanoiu Adrian³⁴,Jacquemont Charlotte³⁴,Jelic Vesna³⁴,Jessen Frank³⁴,Jiao Jieqing³⁴,Jofresa Sara³⁴,Jonsson Cathrine³⁴,Kaliukhovich Dzmitry³⁴,Kern Silke³⁴,Kivipelto Miia³⁴,Knezevic Iva³⁴,Kuchcinski Grégory³⁴,Laforce Manon³⁴,Lafuente Asunción³⁴,Lala Françoise³⁴,Lammertsma Adriaan³⁴,Lax Michelle³⁴,Lebouvier Thibaud³⁴,Lee Ho-Yun³⁴,Lee Lean³⁴,Leeuwis Annebet³⁴,Lefort Amandine³⁴,Legrand Jean-François³⁴,Leroy Mélanie³⁴,Lesoil Markowski Constance³⁴,Levy Marcel³⁴,Lhommel Renaud³⁴,Lopes Renaud³⁴,Lopes Alves Isadora³⁴,Lorenzini Luigi³⁴,Lorette Adrien³⁴,Luckett Emma³⁴,Lundin Marie³⁴,Mackowiak Marie-Anne³⁴,Malotaux Vincent³⁴,Manber Richard³⁴,Manyakov Nikolay³⁴,Markiewicz Pawel³⁴,Marne Paula³⁴,Marquié Marta³⁴,Martín Elvira³⁴,Martínez Joan³⁴,Martinez Lage Pablo³⁴,Mastenbroek Sophie E.³⁴,Maureille Aurélien³⁴,Meersmans Karen³⁴,Mett Anja³⁴,Milne Joseph³⁴,Minguillón Carolina³⁴,Modat Marc³⁴,Molinuevo José Luis³⁴,Montrreal Laura³⁴,Moro Christian³⁴,Müller Theresa³⁴,Muniz Graciela³⁴,Mutsarts Henk Jan³⁴,Nilsson Ted³⁴,Ninerola Aida³⁴,Nordberg Agneta³⁴,Novaes Wilse³⁴,Nuno Carmelo Pires Silva Joao³⁴,Operto Greg³⁴,Orellana Adela³⁴,Ousset Pierre-Jean³⁴,Outteryck Olivier³⁴,Pallardy Amandine³⁴,Palombit Alessandro³⁴,Pancho Ana³⁴,Pappon Martin³⁴,Paquet Claire³⁴,Pariente Jérémie³⁴,Pasquier Florence³⁴,Payoux Pierre³⁴,Peaker Harry³⁴,Pelejà Esther³⁴,Pennetier Delphine³⁴,Pérez-Cordón Alba³⁴,Perissinotti Andrés³⁴,Perrenoud Matthieu Paul³⁴,Petit Sandrine³⁴,Petyt Grégory³⁴,Pfeil Julia³⁴,Pirotte Blanche³⁴,Pla Sandra³⁴,Plaza Wuthrich Sonia³⁴,Poitrine Lea³⁴,Pollet Marianne³⁴,Poncelet Jean-Benoit³⁴,Prior John³⁴,Pruvo Jean-Pierre³⁴,Putallaz Pauline³⁴,Queneau Mathieu³⁴,Quenon Lisa³⁴,Rădoi Andreea³⁴,Rafiq Marie³⁴,Ramage Fiona³⁴,Ramis Maribel³⁴,Reinwald Michael³⁴,Rios Gonzalo³⁴,Ritchie Craig³⁴,Rodriguez Elena³⁴,Rollin Adeline³⁴,Rouaud Olivier³⁴,Sacuiu Simona³⁴,Saint-Aubert Laure³⁴,Sala Arianna³⁴,Salabert Anne-Sophie³⁴,Saldias Jon³⁴,Salvadó Gemma³⁴,Sanabria Angela³⁴,Sannemann Lena³⁴,Sastre Nathalie³⁴,Savina Daniela³⁴,Savitcheva Irina³⁴,Schaeverbeke Jolien³⁴,Scheltens Philip³⁴,Schildermans Carine³⁴,Schmidt Mark³⁴,Schöll Michael³⁴,Schuermans Jeroen³⁴,Semah Franck³⁴,Shekari Mahnaz³⁴,Skoog Ingmar³⁴,Sotolongo-Grau Oscar³⁴,Stephens Andrew³⁴,Stewart Tiffany³⁴,Stutzmann Jennyfer³⁴,Tait Murray³⁴,Tárraga Lluis³⁴,Tartari Juan Pablo³⁴,Tysen-backstrom Ann-christine³⁴,Valero Sergi³⁴,Vallez Garcia David³⁴,van Berckel Bart N.M.³⁴,van Essen Martijn³⁴,Van Laere Koen³⁴,van Leur Jeroen³⁴,van Maurik Ingrid S.³⁴,Vandenberghe Rik³⁴,Vellas Bruno³⁴,Virolinen Jukka³⁴,Visser Pieter Jelle³⁴,Walker Zuzana³⁴,Walles Håkan³⁴,Wallin Emilia³⁴,Whitelaw Grant³⁴,Wimberley Catriona³⁴,Win Zarni³⁴,Wink Alle Meije³⁴,Wolz Robin³⁴,Woodside John³⁴,Yaqub Maqsood³⁴,Zettergren Anna³⁴,Zeyen Philip³⁴,

Affiliation:

1. Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland

2. Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland

3. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

4. Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC)–Location VUmc, Amsterdam, the Netherlands

5. Institute of Neurology, Institute of Healthcare Engineering, University College London, London, United Kingdom

6. Alzheimer Center, Department of Neurology, Amsterdam University Medical Centers–Location VUmc, Amsterdam, the Netherlands

7. Department of Epidemiology and Data Science, Amsterdam University Medical Centers–Location VUmc, Amsterdam, the Netherlands

8. Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland

9. Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland

10. Gérontopôle, Department of Geriatrics, Toulouse University Hospital, Toulouse, France

11. Maintain Aging Research Team, CERPOP, Inserm, Université Paul Sabatier, Toulouse, France

12. Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France

13. Toulouse NeuroImaging Center (ToNIC), UMR1214 Inserm, Université de Toulouse III, Toulouse, France

14. Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain

15. H. Lundbeck, Copenhagen, Denmark

16. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain

17. Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain

18. Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain

19. Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

20. German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany

21. Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Germany

22. Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

23. Excellence Cluster Cellular Stress Responses in Aging-Related Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany

24. Department of Neurobiology, Care Sciences and Society, Center of Alzheimer Research, Karolinska Institutet, Stockholm, Sweden

25. Theme Aging, Karolinska University Hospital, Stockholm, Sweden

26. Medical Radiation Physics and Nuclear Medicine, Section for Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden

27. Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital–Huddinge, Stockholm, Sweden

28. Division of Psychiatry, University College London, London, United Kingdom

29. St Margaret’s Hospital, Essex Partnership University NHS Foundation Trust, Essex, United Kingdom

30. Division of Neurology, Department of Brain Sciences, Imperial College London, London, United Kingdom

31. Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland

32. Life Molecular Imaging, Berlin, Germany

33. GE Healthcare, Amersham, United Kingdom

34. for the Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Consortium

Abstract

ImportanceAmyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed studies demonstrating its clinical effect.ObjectiveTo assess the clinical effect of amyloid PET in memory clinic patients.Design, Setting, and ParticipantsThe AMYPAD-DPMS is a prospective randomized clinical trial in 8 European memory clinics. Participants were allocated (using a minimization method) to 3 study groups based on the performance of amyloid PET: arm 1, early in the diagnostic workup (within 1 month); arm 2, late in the diagnostic workup (after a mean [SD] 8 [2] months); or arm 3, if and when the managing physician chose. Participants were patients with subjective cognitive decline plus (SCD+; SCD plus clinical features increasing the likelihood of preclinical Alzheimer disease), mild cognitive impairment (MCI), or dementia; they were assessed at baseline and after 3 months. Recruitment took place between April 16, 2018, and October 30, 2020. Data analysis was performed from July 2022 to January 2023.InterventionAmyloid PET.Main Outcome and MeasureThe main outcome was the difference between arm 1 and arm 2 in the proportion of participants receiving an etiological diagnosis with a very high confidence (ie, ≥90% on a 50%-100% visual numeric scale) after 3 months.ResultsA total of 844 participants were screened, and 840 were enrolled (291 in arm 1, 271 in arm 2, 278 in arm 3). Baseline and 3-month visit data were available for 272 participants in arm 1 and 260 in arm 2 (median [IQR] age: 71 [65-77] and 71 [65-77] years; 150/272 male [55%] and 135/260 male [52%]; 122/272 female [45%] and 125/260 female [48%]; median [IQR] education: 12 [10-15] and 13 [10-16] years, respectively). After 3 months, 109 of 272 participants (40%) in arm 1 had a diagnosis with very high confidence vs 30 of 260 (11%) in arm 2 (P &lt; .001). This was consistent across cognitive stages (SCD+: 25/84 [30%] vs 5/78 [6%]; P &lt; .001; MCI: 45/108 [42%] vs 9/102 [9%]; P &lt; .001; dementia: 39/80 [49%] vs 16/80 [20%]; P &lt; .001).Conclusion and RelevanceIn this study, early amyloid PET allowed memory clinic patients to receive an etiological diagnosis with very high confidence after only 3 months compared with patients who had not undergone amyloid PET. These findings support the implementation of amyloid PET early in the diagnostic workup of memory clinic patients.Trial RegistrationEudraCT Number: 2017-002527-21

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

Link

https://jamanetwork.com/journals/jamaneurology/articlepdf/2804755/jamaneurology_altomare_2023_oi_230022_1686342381.06859.pdf

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