Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

Author:

Naj Adam C.1,Jun Gyungah2,Reitz Christiane3,Kunkle Brian W.4,Perry William4,Park Yo Son5,Beecham Gary W.6,Rajbhandary Ruchita A.4,Hamilton-Nelson Kara L.4,Wang Li-San7,Kauwe John S. K.8,Huentelman Matthew J.9,Myers Amanda J.10,Bird Thomas D.11,Boeve Bradley F.12,Baldwin Clinton T.13,Jarvik Gail P.14,Crane Paul K.15,Rogaeva Ekaterina16,Barmada M. Michael17,Demirci F. Yesim17,Cruchaga Carlos18,Kramer Patricia L.19,Ertekin-Taner Nilufer20,Hardy John21,Graff-Radford Neill R.20,Green Robert C.22,Larson Eric B.23,St. George-Hyslop Peter H.24,Buxbaum Joseph D.25,Evans Denis A.26,Schneider Julie A.27,Lunetta Kathryn L.28,Kamboh M. Ilyas29,Saykin Andrew J.30,Reiman Eric M.31,De Jager Philip L.32,Bennett David A.33,Morris John C.34,Montine Thomas J.35,Goate Alison M.18,Blacker Deborah36,Tsuang Debby W.37,Hakonarson Hakon38,Kukull Walter A.39,Foroud Tatiana M.40,Martin Eden R.6,Haines Jonathan L.41,Mayeux Richard P.42,Farrer Lindsay A.43,Schellenberg Gerard D.7,Pericak-Vance Margaret A.6,Albert Marilyn S.44,Albin Roger L.45,Apostolova Liana G.46,Arnold Steven E.47,Barber Robert48,Barnes Lisa L.49,Beach Thomas G.50,Becker James T.51,Beekly Duane52,Bigio Eileen H.53,Bowen James D.54,Boxer Adam55,Burke James R.56,Cairns Nigel J.57,Cantwell Laura B.7,Cao Chuanhai58,Carlson Chris S.59,Carney Regina M.10,Carrasquillo Minerva M.60,Carroll Steven L.61,Chui Helena C.62,Clark David G.63,Corneveaux Jason9,Cribbs David H.64,Crocco Elizabeth A.10,DeCarli Charles65,DeKosky Steven T.66,Dick Malcolm67,Dickson Dennis W.60,Duara Ranjan68,Faber Kelley M.40,Fallon Kenneth B.61,Farlow Martin R.69,Ferris Steven70,Frosch Matthew P.71,Galasko Douglas R.72,Ganguli Mary73,Gearing Marla74,Geschwind Daniel H.75,Ghetti Bernardino76,Gilbert John R.6,Glass Jonathan D.77,Growdon John H.78,Hamilton Ronald L.79,Harrell Lindy E.63,Head Elizabeth80,Honig Lawrence S.81,Hulette Christine M.82,Hyman Bradley T.78,Jicha Gregory A.83,Jin Lee-Way84,Karydas Anna55,Kaye Jeffrey A.85,Kim Ronald86,Koo Edward H.72,Kowall Neil W.87,Kramer Joel H.88,LaFerla Frank M.89,Lah James J.77,Leverenz James B.35,Levey Allan I.77,Li Ge90,Lieberman Andrew P.91,Lin Chiao-Feng7,Lopez Oscar L.92,Lyketsos Constantine G.93,Mack Wendy J.94,Martiniuk Frank95,Mash Deborah C.96,Masliah Eliezer97,McCormick Wayne C.15,McCurry Susan M.98,McDavid Andrew N.59,McKee Ann C.87,Mesulam Marsel99,Miller Bruce L.55,Miller Carol A.100,Miller Joshua W.84,Murrell Jill R.101,Olichney John M.65,Pankratz Vernon S.102,Parisi Joseph E.103,Paulson Henry L.104,Peskind Elaine90,Petersen Ronald C.12,Pierce Aimee64,Poon Wayne W.67,Potter Huntington58,Quinn Joseph F.105,Raj Ashok58,Raskind Murray90,Reisberg Barry106,Ringman John M.46,Roberson Erik D.63,Rosen Howard J.55,Rosenberg Roger N.107,Sano Mary108,Schneider Lon S.109,Seeley William W.55,Smith Amanda G.58,Sonnen Joshua A.35,Spina Salvatore76,Stern Robert A.110,Tanzi Rudolph E.78,Thornton-Wells Tricia A.111,Trojanowski John Q.7,Troncoso Juan C.112,Valladares Otto7,Van Deerlin Vivianna M.7,Van Eldik Linda J.113,Vardarajan Badri N.114,Vinters Harry V.115,Vonsattel Jean Paul116,Weintraub Sandra117,Welsh-Bohmer Kathleen A.118,Williamson Jennifer81,Wishnek Sarah4,Woltjer Randall L.119,Wright Clinton B.120,Younkin Steven G.60,Yu Chang-En15,Yu Lei121

Affiliation:

1. Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia

2. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts

3. Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York7Gertrude H. Sergievsky Center, Columbia University, New York, New York8Department of Neurology, Columbia University, New York, New

4. John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida

5. The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida

6. John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida

7. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia

8. Department of Biology, Brigham Young University, Provo, Utah

9. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona

10. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida

11. Department of Neurology, University of Washington, Seattle15Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington

12. Department of Neurology, Mayo Clinic, Rochester, Minnesota

13. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts

14. Department of Genome Sciences, University of Washington, Seattle18Division of Medical Genetics, Department of Medicine, University of Washington, Seattle

15. Department of Medicine, University of Washington, Seattle

16. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada

17. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania

18. Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri

19. Department of Neurology, Oregon Health & Science University, Portland24Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland

20. Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida

21. Institute of Neurology, University College London, London, England

22. Division of Genetics, Department of Medicine, and Partners Center for Personalized Genetic Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

23. Department of Medicine, University of Washington, Seattle29Group Health Research Institute, Group Health Cooperative, Seattle, Washington

24. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada30Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, England

25. Department of Neuroscience, Mount Sinai School of Medicine, New York, New York32Department of Psychiatry, Mount Sinai School of Medicine, New York, New York33Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York

26. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois

27. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois36Neuropathology, Department of Pathology, Rush University Medical Center, Chicago, Illinois

28. Department of Biostatistics, Boston University, Boston, Massachusetts

29. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania37Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania

30. Department of Medical and Molecular Genetics, Indiana University, Indianapolis39Department of Radiology and Imaging Sciences, Indiana University, Indianapolis

31. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona40Arizona Alzheimer’s Consortium, Phoenix41Department of Psychiatry, University of Arizona, Phoenix42Banner Alzheimer’s Institute, Phoenix, Arizona

32. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts44Program in Medical and Population Genetics, Broad Ins

33. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois45Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois

34. Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri47Department of Neurology, Washington University in St Louis, St Louis, Missouri

35. Department of Pathology, University of Washington, Seattle

36. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts50Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston

37. Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington51Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle

38. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

39. Department of Epidemiology, University of Washington, Seattle

40. Department of Medical and Molecular Genetics, Indiana University, Indianapolis

41. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee55Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee

42. Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York57Gertrude H. Sergievsky Center, Columbia University, New York, New York58Department of Neurology, Columbia University, New York, New York

43. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts59Department of Epidemiology, Bos

44. Department of Neurology, Johns Hopkins University, Baltimore, Maryland

45. Department of Neurology, University of Michigan, Ann Arbor63Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan64Michigan Alzheimer Disease Center, Ann Arbor

46. Department of Neurology, University of California Los Angeles, Los Angeles

47. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia

48. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth

49. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois68Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois

50. Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona

51. Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

52. National Alzheimer's Coordinating Center, University of Washington, Seattle

53. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois73Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois

54. Swedish Medical Center, Seattle, Washington

55. Department of Neurology, University of California San Francisco, San Francisco

56. Department of Medicine, Duke University, Durham, North Carolina

57. Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri

58. USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa

59. Fred Hutchinson Cancer Research Center, Seattle, Washington

60. Department of Neuroscience, Mayo Clinic, Jacksonville, Florida

61. Department of Pathology, University of Alabama at Birmingham, Birmingham

62. Department of Neurology, University of Southern California, Los Angeles

63. Department of Neurology, University of Alabama at Birmingham, Birmingham

64. Department of Neurology, University of California Irvine, Irvine

65. Department of Neurology, University of California Davis, Sacramento

66. University of Virginia School of Medicine, Charlottesville

67. Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine

68. Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida

69. Department of Neurology, Indiana University, Indianapolis

70. Department of Psychiatry, New York University, New York

71. C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown

72. Department of Neurosciences, University of California San Diego, La Jolla

73. Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania

74. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia93Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia

75. Neurogenetics Program, University of California Los Angeles, Los Angeles

76. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis

77. Department of Neurology, Emory University, Atlanta, Georgia

78. Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston

79. Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania

80. Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington

81. Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York

82. Department of Pathology, Duke University, Durham, North Carolina

83. Sanders-Brown Center on Aging, Department Neurology, University of Kentucky, Lexington

84. Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento

85. Department of Neurology, Oregon Health & Science University, Portland103Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon

86. Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine

87. Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts

88. Department of Neuropsychology, University of California San Francisco, San Francisco

89. Department of Neurobiology and Behavior, University of California Irvine, Irvine

90. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle

91. Department of Pathology, University of Michigan, Ann Arbor

92. Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania

93. Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland

94. Department of Preventive Medicine, University of Southern California, Los Angeles

95. Department of Medicine - Pulmonary, New York University, New York

96. Department of Neurology, University of Miami, Miami, Florida

97. Department of Neurosciences, University of California San Diego, La Jolla113Department of Pathology, University of California San Diego, La Jolla

98. School of Nursing Northwest Research Group on Aging, University of Washington, Seattle

99. Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois115Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

100. Department of Pathology, University of Southern California, Los Angeles

101. Department of Medical and Molecular Genetics, Indiana University, Indianapolis95Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis

102. Department of Biostatistics, Mayo Clinic, Rochester, Minnesota

103. Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota119Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

104. Department of Neurology, University of Michigan, Ann Arbor

105. Department of Neurology, Oregon Health & Science University, Portland

106. Department of Psychiatry, New York University, New York120Alzheimer's Disease Center, New York University, New York

107. Department of Neurology, University of Texas Southwestern, Dallas

108. Department of Psychiatry, Mount Sinai School of Medicine, New York, New York

109. Department of Neurology, University of Southern California, Los Angeles122Department of Psychiatry, University of Southern California, Los Angeles

110. Department of Neurology, Boston University, Boston, Massachusetts

111. Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee

112. Department of Pathology, Johns Hopkins University, Baltimore, Maryland

113. Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington

114. Department of Neurology, Columbia University, New York, New York

115. Department of Neurology, University of California Los Angeles, Los Angeles125Department of Pathology & Laboratory Medicine, University of California Los Angeles, Los Angeles

116. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York

117. Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois127Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois

118. Department of Medicine, Duke University, Durham, North Carolina128Department of Psychiatry & Behavioral Sciences, Duke University, Durham, North Carolina

119. Department of Pathology, Oregon Health & Science University, Portland

120. Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida

121. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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