Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

Author:

Ghani Mahdi1,Reitz Christiane2,Cheng Rong3,Vardarajan Badri Narayan4,Jun Gyungah5,Sato Christine1,Naj Adam6,Rajbhandary Ruchita6,Wang Li-San7,Valladares Otto7,Lin Chiao-Feng7,Larson Eric B.8,Graff-Radford Neill R.9,Evans Denis10,De Jager Philip L.11,Crane Paul K.12,Buxbaum Joseph D.13,Murrell Jill R.14,Raj Towfique15,Ertekin-Taner Nilufer9,Logue Mark16,Baldwin Clinton T.16,Green Robert C.17,Barnes Lisa L.18,Cantwell Laura B.7,Fallin M. Daniele19,Go Rodney C. P.20,Griffith Patrick A.21,Obisesan Thomas O.22,Manly Jennifer J.23,Lunetta Kathryn L.24,Kamboh M. Ilyas25,Lopez Oscar L.26,Bennett David A.27,Hendrie Hugh28,Hall Kathleen S.29,Goate Alison M.30,Byrd Goldie S.31,Kukull Walter A.32,Foroud Tatiana M.33,Haines Jonathan L.34,Farrer Lindsay A.35,Pericak-Vance Margaret A.6,Lee Joseph H.2,Schellenberg Gerard D.7,St. George-Hyslop Peter1,Mayeux Richard2,Rogaeva Ekaterina1

Affiliation:

1. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

2. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York3Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York4

3. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York

4. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York

5. Department of Medicine (Biomedical Genetics), Boston University, Boston, Massachusetts6Department of Biostatistics, Boston University, Boston, Massachusetts7Department of Ophthalmology, Boston University, Boston, Massachusetts

6. The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida

7. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia

8. Department of Medicine, University of Washington, Seattle11Group Health Research Institute, Group Health, Seattle, Washington

9. Department of Neuroscience, Mayo Clinic, Jacksonville, Florida13Department of Neurology, Mayo Clinic, Jacksonville, Florida

10. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois

11. Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts16Harvard Medical School, Boston, Massachusetts17Program in Medical and Population Genetics, The Broad Institute, Cambridge, Ma

12. Department of Medicine, University of Washington, Seattle

13. Department of Psychiatry, Mount Sinai School of Medicine, New York, New York19Department of Genetics and Genomics Sciences, Mount Sinai School of Medicine, New York, New York20Department of Neuroscience, Mount Sinai School of Medicine, New York, New York2

14. Department of Medical and Molecular Genetics, Indiana University, Indianapolis

15. Harvard Medical School, Boston, Massachusetts

16. Department of Medicine (Biomedical Genetics), Boston University, Boston, Massachusetts

17. Harvard Medical School, Boston, Massachusetts23Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts24Partners Center for Personalized Genetic Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

18. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois26Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois

19. Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, Maryland

20. School of Public Health, University of Alabama at Birmingham

21. SABA University School of Medicine, SABA, Dutch Caribbean

22. Division of Geriatrics, Howard University Hospital, Washington, DC

23. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York4Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York

24. Department of Biostatistics, Boston University, Boston, Massachusetts

25. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania32Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania

26. Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania

27. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois33Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois

28. Indiana University Center for Aging Research, Indianapolis35Department of Psychiatry, Indiana University School of Medicine, Indianapolis36Regenstrief Institute Inc, Indianapolis, Indiana

29. Department of Psychiatry, Indiana University School of Medicine, Indianapolis

30. Hope Center Program on Protein Aggregation and Neurodegeneration, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri

31. Department of Biology, North Carolina A & T University, Greensboro

32. National Alzheimer’s Coordinating Center, Department of Epidemiology, University of Washington, Seattle

33. Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois

34. Vanderbilt Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee

35. Department of Medicine (Biomedical Genetics), Boston University, Boston, Massachusetts6Department of Biostatistics, Boston University, Boston, Massachusetts7Department of Ophthalmology, Boston University, Boston, Massachusetts41Department of Neurology, Bo

Publisher

American Medical Association (AMA)

Subject

Neurology (clinical)

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