Clinical Trial Simulations Based on Genetic Stratification and the Natural History of a Functional Outcome Measure in Creutzfeldt-Jakob Disease

Author:

Mead Simon1,Burnell Matthew2,Lowe Jessica3,Thompson Andrew3,Lukic Ana3,Porter Marie-Claire3,Carswell Christopher3,Kaski Diego3,Kenny Janna3,Mok Tze How3,Bjurstrom Nina3,Franko Edit3,Gorham Michele3,Druyeh Ronald4,Wadsworth Jonathan D. F.4,Jaunmuktane Zane5,Brandner Sebastian6,Hyare Harpreet3,Rudge Peter1,Walker A. Sarah7,Collinge John1

Affiliation:

1. Medical Research Council Prion Unit, Department of Neurodegnerative Disease, University College London Institute of Neurology, London, England2National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NH

2. Department of Statistical Science, Faculty of Mathematical and Physical Sciences, University College London, London, England

3. National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Trust, London, England

4. Medical Research Council Prion Unit, Department of Neurodegnerative Disease, University College London Institute of Neurology, London, England

5. Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Trust, London, England

6. Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Trust, London, England5Department of Neurodegenerative Disease, University College London Institute of Neurology, London, England

7. MRC Clinical Trials Unit at University College London, London, England

Publisher

American Medical Association (AMA)

Subject

Clinical Neurology

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