Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases

Author:

Zeng Chenjie1,Bastarache Lisa A.2,Tao Ran3,Venner Eric4,Hebbring Scott5,Andujar Justin D.67,Bland Sarah T.2,Crosslin David R.8,Pratap Siddharth9,Cooley Ayorinde10,Pacheco Jennifer A.11,Christensen Kurt D.1213,Perez Emma14,Zawatsky Carrie L. Blout14,Witkowski Leora15,Zouk Hana1617,Weng Chunhua18,Leppig Kathleen A.19,Sleiman Patrick M. A.2021,Hakonarson Hakon2021,Williams Marc. S.22,Luo Yuan23,Jarvik Gail P.2425,Green Robert C.26,Chung Wendy K.2728,Gharavi Ali G.2930,Lennon Niall J.31,Rehm Heidi L.323334,Gibbs Richard A.4,Peterson Josh F.2,Roden Dan M.23536,Wiesner Georgia L.67,Denny Joshua C.1

Affiliation:

1. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland

2. Center for Precision Medicine, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee

3. Department of Biostatistics, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee

4. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas

5. Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, Wisconsin

6. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

7. Clinical and Translational Hereditary Cancer Program, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee

8. Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle

9. School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee

10. Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee

11. Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

12. PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts

13. Department of Population Medicine, Harvard Medical School, Boston, Massachusetts

14. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

15. Centre Universitaire de Santé McGill, McGill University Health Centre, Montreal, Quebec, Canada

16. Laboratory for Molecular Medicine, Partners Healthcare Personalized Medicine, Cambridge, Massachusetts

17. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston

18. Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York

19. Genetic Services and Kaiser Permanente Washington Health Research Institute, Kaiser Permanente of Washington, Seattle

20. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

21. Division of Human Genetics, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia

22. Genomic Medicine Institute, Geisinger, Danville, Pennsylvania

23. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

24. Department of Medicine (Medical Genetics), University of Washington, Seattle

25. Department of Genome Sciences, University of Washington, Seattle

26. Brigham and Women’s Hospital, Broad Institute, Ariadne Labs and Harvard Medical School, Boston, Massachusetts

27. Department of Pediatrics, Columbia University, New York, New York

28. Department of Medicine, Columbia University, New York, New York

29. Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York

30. Center for Precision Medicine and Genomics, Department of Medicine, Columbia University Irving Medical Center, New York, New York

31. Broad Institute of MIT and Harvard, Cambridge, Massachusetts

32. Medical & Population Genetics Program and Genomics Platform, Broad Institute of MIT and Harvard Cambridge, Cambridge, Massachusetts

33. Center for Genomic Medicine, Massachusetts General Hospital, Boston

34. Department of Pathology, Harvard Medical School, Boston, Massachusetts

35. Divisions of Cardiovascular Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

36. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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