Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

Author:

,Mavaddat Nasim1,Dorling Leila1,Carvalho Sara1,Allen Jamie1,González-Neira Anna2,Keeman Renske3,Bolla Manjeet K.1,Dennis Joe1,Wang Qin1,Ahearn Thomas U.4,Andrulis Irene L.56,Beckmann Matthias W.7,Behrens Sabine8,Benitez Javier29,Bermisheva Marina10,Blomqvist Carl11,Bogdanova Natalia V.121314,Bojesen Stig E.151617,Briceno Ignacio18,Brüning Thomas19,Camp Nicola J.20,Campbell Archie2122,Castelao Jose E.23,Chang-Claude Jenny824,Chanock Stephen J.4,Chenevix-Trench Georgia25,Christiansen Hans12,Czene Kamila26,Dörk Thilo13,Eriksson Mikael26,Evans D. Gareth2728,Fasching Peter A.729,Figueroa Jonine D.2230,Flyger Henrik31,Gabrielson Marike26,Gago-Dominguez Manuela3233,Geisler Jürgen3435,Giles Graham G.363738,Guénel Pascal39,Hadjisavvas Andreas4041,Hahnen Eric4243,Hall Per2644,Hamann Ute45,Hartikainen Jaana M.4647,Hartman Mikael484950,Hoppe Reiner5152,Howell Anthony53,Jakubowska Anna5455,Jung Audrey8,Khusnutdinova Elza K.1056,Kristensen Vessela N.5758,Li Jingmei4959,Lim Swee Ho6061,Lindblom Annika6263,Loizidou Maria A.4041,Lophatananon Artitaya64,Lubiński Jan54,Madsen Michael J.20,Mannermaa Arto464765,Manoochehri Mehdi45,Margolin Sara4466,Mavroudis Dimitrios67,Milne Roger L.363738,Mohd Taib Nur Aishah68,Morra Anna3,Muir Kenneth64,Obi Nadia69,Osorio Ana270,Park-Simon Tjoung-Won13,Peterlongo Paolo71,Radice Paolo72,Saloustros Emmanouil73,Sawyer Elinor J.74,Schmutzler Rita K.424375,Shah Mitul76,Sim Xueling48,Southey Melissa C.363877,Thorne Heather7879,Tomlinson Ian8081,Torres Diana4582,Truong Thérèse39,Yip Cheng Har6883,Spurdle Amanda B.25,Vreeswijk Maaike P.G.84,Dunning Alison M.76,García-Closas Montserrat4,Pharoah Paul D.P.176,Kvist Anders85,Muranen Taru A.86,Nevanlinna Heli86,Teo Soo Hwang6887,Devilee Peter8488,Schmidt Marjanka K.389,Easton Douglas F.176

Affiliation:

1. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England

2. Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

3. Division of Molecular Pathology, the Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands

4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland

5. Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada

6. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

7. Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

8. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

9. Biomedical Network on Rare Diseases, Madrid, Spain

10. Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia

11. Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

12. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

13. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

14. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus

15. Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

16. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

17. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

18. Medical Faculty, Universidad de La Sabana, Bogota, Colombia

19. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany

20. Department of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City

21. Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, Scotland

22. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

23. Oncology and Genetics Unit, Instituto de Investigación Sanitaria Galicia Sur, Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain

24. Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

25. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

26. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

27. Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England

28. North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, England

29. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles

30. Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, Scotland

31. Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

32. Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain

33. Moores Cancer Center, University of California San Diego, La Jolla

34. Department of Oncology, Akershus University Hospital, Lørenskog, Norway

35. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Campus at Akershus University Hospital, Norway

36. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia

37. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia

38. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia

39. Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Villejuif, France

40. Department of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus

41. Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus

42. Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

43. Center for Integrated Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

44. Department of Oncology, Södersjukhuset, Stockholm, Sweden

45. Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany

46. Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland

47. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

48. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore

49. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore

50. Department of Surgery, National University Health System, Singapore, Singapore

51. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

52. University of Tübingen, Tübingen, Germany

53. Division of Cancer Sciences, University of Manchester, Manchester, England

54. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

55. Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland

56. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia

57. Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway

58. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

59. Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore

60. Breast Department, KK Women’s and Children’s Hospital, Singapore, Singapore

61. SingHealth Duke-NUS Breast Centre, Singapore, Singapore

62. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

63. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

64. Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, England

65. Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland

66. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

67. Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece

68. Department of Surgery, Faculty of Medicine University of Malaya, UM Cancer Research Institute, Kuala Lumpur, Malaysia

69. Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

70. Centro de Investigación en Red de Enfermedades Raras, Madrid, Spain

71. Genome Diagnostics Program, IFOM–the FIRC Institute of Molecular Oncology, Milan, Italy

72. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

73. Department of Oncology, University Hospital of Larissa, Larissa, Greece

74. School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy’s Campus, King’s College London, London, England

75. Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

76. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, England

77. Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia

78. Research Department, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia

79. Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia

80. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, England

81. Wellcome Trust Centre for Human Genetics and Oxford National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, England

82. Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia

83. Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia

84. Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands

85. Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

86. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

87. Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia

88. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands

89. Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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