Association of Staphylococcus aureus Colonization With Severity of Acute Radiation Dermatitis in Patients With Breast or Head and Neck Cancer

Author:

Kost Yana1,Rzepecki Alexandra K.1,Deutsch Alana1,Birnbaum Mathew R.1,Ohri Nitin2,Hosgood H. Dean3,Lin Juan3,Daily Johanna P.4,Shinoda Kosaku56,McLellan Beth N.1

Affiliation:

1. Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York

2. Department of Radiation Oncology, Montefiore Medical Center, Bronx, New York

3. Department of Epidemiology and Population Health (Biostatistics), Albert Einstein College of Medicine, Bronx, New York

4. Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York

5. Division of Endocrinology and Diabetes, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York

6. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York

Abstract

ImportancePathogenesis of acute radiation dermatitis (ARD) is not completely understood. Pro-inflammatory cutaneous bacteria may contribute to cutaneous inflammation after radiation therapy.ObjectiveTo evaluate whether nasal colonization with Staphylococcus aureus (SA) before radiation therapy is associated with ARD severity in patients with breast or head and neck cancer.Design, Setting, and ParticipantsThis prospective cohort study with observers blinded to colonization status was conducted from July 2017 to May 2018 at an urban academic cancer center. Patients aged 18 years or older with breast or head and neck cancer and plans for fractionated radiation therapy (≥15 fractions) with curative intent were enrolled via convenience sampling. Data were analyzed from September to October 2018.ExposuresStaphylococcus aureus colonization status before radiation therapy (baseline).Main Outcomes and MeasuresThe primary outcome was ARD grade using the Common Terminology Criteria for Adverse Event Reporting, version 4.03.ResultsAmong 76 patients analyzed, mean (SD) age was 58.5 (12.6) years and 56 (73.7%) were female. All 76 patients developed ARD: 47 (61.8%) with grade 1, 22 (28.9%) with grade 2, and 7 (9.2%) with grade 3. The prevalence of baseline nasal SA colonization was higher among patients who developed grade 2 or higher ARD compared with those who developed grade 1 ARD (10 of 29 [34.5%] vs 6 of 47 [12.8%]; P = .02, by χ2 test).Conclusions and RelevanceIn this cohort study, baseline nasal SA colonization was associated with development of grade 2 or higher ARD in patients with breast or head and neck cancer. The findings suggest that SA colonization may play a role in the pathogenesis of ARD.

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3