Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma

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Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma—Reply

Published:2024-06-01 Issue:6 Volume:10 Page:830
ISSN:2374-2437
Container-title:JAMA Oncology
language:en
Short-container-title:JAMA Oncol

Author:

Seo Yongwoo David¹²,Pollack Seth M.³

Affiliation:

1. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston

2. Department of Surgery, University of Washington, Seattle

3. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Publisher

American Medical Association (AMA)

Link

https://jamanetwork.com/journals/jamaoncology/articlepdf/2817453/jamaoncology_seo_2024_lr_240007_1718739248.05677.pdf

Reference5 articles.

1. Toll-like receptor 4 agonist injection with concurrent radiotherapy in patients with metastatic soft tissue sarcoma: a phase 1 nonrandomized controlled trial.;Seo;JAMA Oncol,2023

2. Neoadjuvant therapy induces a potent immune response to sarcoma, dominated by myeloid and B cells.;Goff;Clin Cancer Res,2022

3. In situ vaccination with a TLR9 agonist and local low-dose radiation induces systemic responses in untreated indolent lymphoma.;Frank;Cancer Discov,2018

4. Intratumoral G100, a TLR4 agonist, induces antitumor immune responses and tumor regression in patients with merkel cell carcinoma.;Bhatia;Clin Cancer Res,2019

5. Pembrolizumab combined with low-dose cyclophosphamide and intra-tumoral injection of the toll-like receptor 4 agonist G100 in patients with advanced pretreated soft tissue sarcoma: results from the PEMBROSARC basket study.;Spalato-Ceruso;J Hematol Oncol,2022

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