Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

Author:

Parsons D. Williams1,Roy Angshumoy2,Yang Yaping3,Wang Tao4,Scollon Sarah5,Bergstrom Katie5,Kerstein Robin A.5,Gutierrez Stephanie5,Petersen Andrea K.3,Bavle Abhishek5,Lin Frank Y.6,López-Terrada Dolores H.2,Monzon Federico A.7,Hicks M. John2,Eldin Karen W.7,Quintanilla Norma M.7,Adesina Adekunle M.8,Mohila Carrie A.7,Whitehead William9,Jea Andrew9,Vasudevan Sanjeev A.10,Nuchtern Jed G.11,Ramamurthy Uma12,McGuire Amy L.13,Hilsenbeck Susan G.4,Reid Jeffrey G.14,Muzny Donna M.14,Wheeler David A.15,Berg Stacey L.6,Chintagumpala Murali M.6,Eng Christine M.3,Gibbs Richard A.16,Plon Sharon E.1

Affiliation:

1. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas3The Human Genome Sequencing Center, Baylor College of Medicine, Houston, T

2. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston4The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas5Department of Pathology, Texas Children’s Hospital, Houston6Department of Pathology a

3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas

4. The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas

5. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston

6. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston4The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas

7. Department of Pathology, Texas Children’s Hospital, Houston6Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas

8. The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas5Department of Pathology, Texas Children’s Hospital, Houston6Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas

9. Division of Pediatric Neurosurgery, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas8Department of Surgery, Texas Children’s Hospital, Houston

10. The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas8Department of Surgery, Texas Children’s Hospital, Houston9Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas

11. Texas Children’s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston4The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas8Department of Surgery, Texas Children’s Hospital, Houston9Michael E. DeBakey Departme

12. Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas

13. The Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas11Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas

14. The Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas

15. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas3The Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas4The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas

16. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas3The Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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