Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma-Reference-Cited by-同舟云学术

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Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma

Published:2019-11-01 Issue:11 Volume:5 Page:1566
ISSN:2374-2437
Container-title:JAMA Oncology
language:en
Short-container-title:JAMA Oncol

Author:

Fernández-Martos Carlos¹,Pericay Carles²,Losa Ferran³,García-Carbonero Rocio⁴,Layos Laura⁵,Rodríguez-Salas Nuria⁶,Martin-Richard Marta⁷,Alonso-Orduña Vicente⁸,Vera Ruth⁹,Gallego Javier¹⁰,Capdevila Jaume¹¹,Salud Antonieta¹²,Nogué Miquel¹³,Maurel Joan¹⁴,Guash Inmaculada¹⁵,Montagut Clara¹⁶,Lopez Carlos¹⁷,Macias Ismael²,Jain Rakesh K.¹⁸,Garcia-Albeniz Xabier¹⁹

Affiliation:

1. Fundación Instituto Valenciano de Oncología, Valencia, Spain

2. Hospital de Sabadell Corporació Sanitària Parc Taulí, Barcelona, Spain

3. Hospital Sant Joan Despí Moisès Broggi, Barcelona, Spain

4. Hospital Universitario 12 de Octubre, Madrid, Spain

5. B-ARGO Group Catalan, Institute of Oncology (ICO), Badalona, Spain

6. Hospital Universitario La Paz, Madrid, Spain

7. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

8. Hospital Universitario Miguel Servet, Zaragoza, Spain

9. Hospital de Navarra, Pamplona, Spain

10. Hospital General Universitario de Elche, Alicante, Spain

11. Hospital Universitario Vall d’Hebron, Barcelona, Spain

12. Hospital Universitario Arnau de Vilanova, Lleida, Spain

13. Hospital General de Granollers, Barcelona, Spain

14. Hospital Clinic of Barcelona, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, University of Barcelona, Spain

15. Fundació Althaia de Manresa, Barcelona, Spain

16. Hospital del Mar, Barcelona, Spain

17. Hospital Universitario Marqués de Valdecilla, Santander, Spain

18. Edwin Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston

19. RTI Health Solutions, Barcelona, Spain

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

Link

https://jamanetwork.com/journals/jamaoncology/articlepdf/2749177/jamaoncology_fernndezmartos_2019_oi_190055.pdf

Reference23 articles.

1. Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: grupo cancer de recto 3 study.;Fernández-Martos;J Clin Oncol,2010

2. Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C).;Dewdney;J Clin Oncol,2012

3. Adoption of total neoadjuvant therapy for locally advanced rectal cancer.;Cercek;JAMA Oncol,2018

4. NRG-GI002: a phase II clinical trial platform for total neoadjuvant therapy (TNT) in rectal cancer.;George;J Clin Oncol,2017

5. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.;Jain;Nat Med,2001

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1. Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials;European Journal of Cancer;2024-10

2. mFOLFOX6 versus mFOLFOX6 + aflibercept as neoadjuvant treatment in MRI-defined T3-rectal cancer: a randomized phase-II-trial of the German Rectal Cancer Study Group (CAO/ARO/AIO 0214);ESMO Open;2024-09

3. Combination of neoadjuvant and adjuvant chemotherapy with FOLFOX compared with adjuvant chemotherapy in management of locally advanced rectal cancers: a randomized trial of a promising therapeutic approach;BMC Cancer;2024-07-18

4. Current State of Neoadjuvant Therapy for Locally Advanced Rectal Cancer;The Cancer Journal;2024-07

5. Localized Rectal Cancer: Indian Consensus and Guidelines;Indian Journal of Medical and Paediatric Oncology;2024-02-09

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