Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma

Author:

Mirabello Lisa1,Zhu Bin1,Koster Roelof1,Karlins Eric2,Dean Michael12,Yeager Meredith2,Gianferante Matthew1,Spector Logan G.3,Morton Lindsay M.1,Karyadi Danielle1,Robison Leslie L.4,Armstrong Gregory T.4,Bhatia Smita5,Song Lei1,Pankratz Nathan3,Pinheiro Maisa1,Gastier-Foster Julie M.6,Gorlick Richard7,de Toledo Silvia Regina Caminada8,Petrilli Antonio S.8,Patino-Garcia Ana910,Lecanda Fernando910,Gutierrez-Jimeno Miriam9,Serra Massimo11,Hattinger Claudia11,Picci Piero11,Scotlandi Katia11,Flanagan Adrienne M.1213,Tirabosco Roberto13,Amary Maria Fernanda13,Kurucu Nilgün14,Ilhan Inci Ergurhan14,Ballinger Mandy L.1516,Thomas David M.1516,Barkauskas Donald A.17,Mejia-Baltodano Gerardo18,Valverde Patricia19,Hicks Belynda D.2,Zhu Bin2,Wang Mingyi2,Hutchinson Amy A.2,Tucker Margaret1,Sampson Joshua1,Landi Maria T.1,Freedman Neal D.1,Gapstur Susan20,Carter Brian20,Hoover Robert N.1,Chanock Stephen J.1,Savage Sharon A.1

Affiliation:

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

2. Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland

3. Department of Pediatrics, University of Minnesota, Minneapolis

4. Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee

5. Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham

6. Department of Pathology and Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus

7. Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston

8. Laboratorio de Genetica, Instituto de Oncologia Pediatrica, Grupo de Apoio ao Adolescente e a Crianca com Cancer/Universidade Federal de Sao Paulo, Sao Paulo, Brazil

9. Solid Tumor Division, Department of Pediatrics, University Clinic of Navarra and Center for Applied Medical Research, Navarra Institute for Health Research, Pamplona, Spain

10. Center for Applied Medical Research, University of Navarra, Instituto de Investigacion Sanitaria de Navarra, and Centro de Investigacion Biomedica en Red Cancer, Pamplona, Spain

11. Laboratory of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Ortopedico Rizzoli, Bologna, Italy

12. Research Department of Pathology, UCL Cancer Institute, London, United Kingdom

13. Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, United Kingdom

14. Department of Pediatric Oncology, A.Y. Ankara Oncology Training and Research Hospital, Yenimahalle, Ankara, Turkey

15. Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

16. St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

17. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles

18. Hospital Infantil Manuel De Jesus Rivera, Managua, Nicaragua

19. Unidad Nacional de Oncología Pediatrica, Guatemala City, Guatemala

20. Epidemiology Research Program, American Cancer Society, Atlanta, Georgia

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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