Differentiation Syndrome Associated With Enasidenib, a Selective Inhibitor of Mutant Isocitrate Dehydrogenase 2

Author:

Fathi Amir T.12,DiNardo Courtney D.3,Kline Irina4,Kenvin Laurie4,Gupta Ira4,Attar Eyal C.5,Stein Eytan M.6,de Botton Stephane7,

Affiliation:

1. Department of Medicine, Division of Hematology and Medical Oncology, Massachusetts General Hospital Cancer Center

2. Massachusetts General Hospital, Harvard Medical School, Boston

3. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston

4. Celgene Corporation, Summit, New Jersey

5. Agios Pharmaceuticals, Inc, Cambridge, Massachusetts

6. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

7. Department of Clinical Hematology, Gustave Roussy, Villejuif, France

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

Reference16 articles.

1. Myeloid malignancies and microenvironment.;Korn;Blood,2017

2. Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML.;Sexauer;Blood,2012

3. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.;Stein;Blood,2017

4. The differentiation syndrome in patients with acute promyelocytic leukemia: experience of the pethema group and review of the literature.;Montesinos;Mediterr J Hematol Infect Dis,2011

5. Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.;Tallman;Blood,2000

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