The Case for Allowing Proton Beam Therapy on Head and Neck Cooperative Group Studies

Author:

McCall Neal S.12,Frank Steven J.3,Stokes William A.1

Affiliation:

1. Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia

2. Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

3. Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston

Abstract

This Viewpoint present the case for revisiting the proscription of proton beam therapy in trials of patients with de novo, nonmetastatic head and neck cancer.

Publisher

American Medical Association (AMA)

Reference7 articles.

1. Comparative effectiveness of proton vs photon therapy as part of concurrent chemoradiotherapy for locally advanced cancer.;Baumann;JAMA Oncol,2020

2. TORPEdO: a phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer.;Price;Clin Oncol (R Coll Radiol),2020

3. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls.;Mendenhall;J Clin Oncol,2006

4. Intensity-modulated proton beam therapy or intensity-modulated photon therapy in treating patients with stage III-IVB oropharyngeal cancer. ClinicalTrials.gov identifier: NCT01893307. Updated September 29, 2023. Accessed March 28, 2022. https://clinicaltrials.gov/study/NCT01893307

5. DAHANCA 35: Proton Versus Photon Therapy for Head-neck Cancer (DAHANCA 35). ClinicalTrials.gov identifier: NCT04607694. Updated October 29, 2020. Accessed April 18, 2022. https://clinicaltrials.gov/study/NCT04607694

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