Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Author:

de Moor Marleen H. M.1,van den Berg Stéphanie M.2,Verweij Karin J. H.3,Krueger Robert F.4,Luciano Michelle5,Arias Vasquez Alejandro6,Matteson Lindsay K.4,Derringer Jaime7,Esko Tõnu8,Amin Najaf9,Gordon Scott D.10,Hansell Narelle K.10,Hart Amy B.11,Seppälä Ilkka12,Huffman Jennifer E.13,Konte Bettina14,Lahti Jari15,Lee Minyoung16,Miller Mike4,Nutile Teresa17,Tanaka Toshiko18,Teumer Alexander19,Viktorin Alexander20,Wedenoja Juho21,Abecasis Goncalo R.22,Adkins Daniel E.23,Agrawal Arpana24,Allik Jüri25,Appel Katja26,Bigdeli Timothy B.16,Busonero Fabio27,Campbell Harry28,Costa Paul T.29,Davey Smith George30,Davies Gail5,de Wit Harriet31,Ding Jun18,Engelhardt Barbara E.32,Eriksson Johan G.33,Fedko Iryna O.34,Ferrucci Luigi18,Franke Barbara35,Giegling Ina14,Grucza Richard24,Hartmann Annette M.14,Heath Andrew C.24,Heinonen Kati36,Henders Anjali K.10,Homuth Georg37,Hottenga Jouke-Jan34,Iacono William G.4,Janzing Joost38,Jokela Markus36,Karlsson Robert20,Kemp John P.39,Kirkpatrick Matthew G.31,Latvala Antti40,Lehtimäki Terho12,Liewald David C.5,Madden Pamela A. F.24,Magri Chiara41,Magnusson Patrik K. E.20,Marten Jonathan13,Maschio Andrea27,Medland Sarah E.10,Mihailov Evelin42,Milaneschi Yuri43,Montgomery Grant W.10,Nauck Matthias44,Ouwens Klaasjan G.34,Palotie Aarno45,Pettersson Erik20,Polasek Ozren46,Qian Yong18,Pulkki-Råback Laura36,Raitakari Olli T.47,Realo Anu48,Rose Richard J.49,Ruggiero Daniela17,Schmidt Carsten O.19,Slutske Wendy S.50,Sorice Rossella17,Starr John M.51,St Pourcain Beate52,Sutin Angelina R.53,Timpson Nicholas J.30,Trochet Holly13,Vermeulen Sita54,Vuoksimaa Eero21,Widen Elisabeth55,Wouda Jasper56,Wright Margaret J.10,Zgaga Lina57,Porteous David58,Minelli Alessandra41,Palmer Abraham A.59,Rujescu Dan14,Ciullo Marina17,Hayward Caroline60,Rudan Igor28,Metspalu Andres61,Kaprio Jaakko62,Deary Ian J.5,Räikkönen Katri36,Wilson James F.28,Keltikangas-Järvinen Liisa36,Bierut Laura J.24,Hettema John M.16,Grabe Hans J.63,van Duijn Cornelia M.9,Evans David M.39,Schlessinger David18,Pedersen Nancy L.17,Terracciano Antonio64,McGue Matt65,Penninx Brenda W. J. H.43,Martin Nicholas G.10,Boomsma Dorret I.34

Affiliation:

1. Department of Clinical Child and Family Studies, VU University Amsterdam, Amsterdam, the Netherlands2Department of Methods, VU University Amsterdam, Amsterdam, the Netherlands3Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Ne

2. Department of Research Methodology, Measurement, and Data Analysis, University of Twente, Enschede, the Netherlands

3. Department of Developmental Psychology, EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, the Netherlands6QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia

4. Department of Psychology, University of Minnesota, Minneapolis

5. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland9Department of Psychology, University of Edinburgh, Edinburgh, Scotland

6. Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands11Donders Institute for Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, the Netherlands12Department of Psychiatry, Radboud University

7. Department of Psychology, University of Illinois at Urbana-Champaign, Champaign

8. Estonian Genome Center, University of Tartu, Tartu, Estonia

9. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

10. QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia

11. Department of Human Genetics, University of Chicago, Chicago, Illinois

12. Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland

13. Medical Research Council Human Genetics, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland

14. Department of Psychiatry, University of Halle, Halle, Germany

15. Folkhälsan Research Center, Helsinki, Finland22Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

16. Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond

17. Institute of Genetics and Biophysics “A. Buzzati-Traverso,” National Research Council of Italy, Naples, Italy

18. National Institute on Aging, National Institutes of Health, Baltimore, Maryland

19. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

20. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

21. Department of Public Health, University of Helsinki, Helsinki, Finland

22. Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor

23. Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond

24. Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri

25. Department of Psychology, University of Tartu, Tartu, Estonia33Estonian Academy of Sciences, Tallinn, Estonia

26. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

27. Istituto di Ricerca Genetica e Biomedica, National Research Council of Italy, Monserrato, Italy

28. Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland

29. Behavioral Medicine Research Center, Duke University School of Medicine, Durham, North Carolina

30. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, England

31. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois

32. Department of Computer Science, Princeton University, Princeton, New Jersey

33. Folkhälsan Research Center, Helsinki, Finland41Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland42Vasa Central Hospital, Vasa, Finland43National Institute for Health and Welf

34. Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands

35. Donders Institute for Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, the Netherlands12Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands13Department of Human Genetics, Radboud University Nijmege

36. Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

37. Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

38. Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands

39. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, England45University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia

40. Department of Public Health, University of Helsinki, Helsinki, Finland43National Institute for Health and Welfare, Helsinki, Finland

41. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

42. Estonian Genome Center, University of Tartu, Tartu, Estonia47Department of Biotechnology, University of Tartu, Tartu, Estonia

43. Department of Psychiatry, EMGO+ Institute, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands

44. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

45. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England51Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

46. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia

47. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland54Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

48. Department of Psychology, University of Tartu, Tartu, Estonia

49. Department of Psychological and Brain Sciences, Indiana University, Bloomington

50. Department of Psychological Sciences and Missouri Alcoholism Research Center, University of Missouri, Columbia

51. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland57Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, Scotland

52. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, England58School of Oral and Dental Sciences, University of Bristol, Bristol, England59School of Experimental Psychology, Unive

53. National Institute on Aging, National Institutes of Health, Baltimore, Maryland60College of Medicine, Florida State University, Tallahassee

54. Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands61Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands

55. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

56. Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands4Department of Research Methodology, Measurement, and Data Analysis, University of Twente, Enschede, the Netherlands

57. Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland62Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland

58. Medical Genetics Section, University of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland

59. Department of Human Genetics, University of Chicago, Chicago, Illinois39Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois

60. Medical Research Council Human Genetics, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland64Generation Scotland, University of Edinburgh, Centre for Genomic and Experimental Medicine,

61. Estonian Genome Center, University of Tartu, Tartu, Estonia33Estonian Academy of Sciences, Tallinn, Estonia

62. Department of Public Health, University of Helsinki, Helsinki, Finland43National Institute for Health and Welfare, Helsinki, Finland51Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

63. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany65Department of Psychiatry and Psychotherapy, HELIOS Hospital Stralsund, Stralsund, Germany

64. Folkhälsan Research Center, Helsinki, Finland60College of Medicine, Florida State University, Tallahassee

65. Department of Psychology, University of Minnesota, Minneapolis66Institute of Public Health, University of Southern Denmark, Odense, Denmark

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health

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