Association Between False Memories and Delusions in Alzheimer Disease-Reference-Cited by-同舟云学术

Association Between False Memories and Delusions in Alzheimer Disease

Published:2023-07-01 Issue:7 Volume:80 Page:700
ISSN:2168-622X
Container-title:JAMA Psychiatry
language:en
Short-container-title:JAMA Psychiatry

Author:

McLachlan Emma¹,Ocal Dilek²,Burgess Neil³⁴,Reeves Suzanne¹,Howard Robert¹,Weiner Michael W.⁵,Aisen Paul⁵,Petersen Ronald⁵,Jack Clifford R.⁵,Jagust William⁵,Trojanowki John Q.⁵,Toga Arthur W.⁵,Beckett Laurel⁵,Green Robert C.⁵,Saykin Andrew J.⁵,Morris John C.⁵,Perrin Richard J.⁵,Shaw Leslie M.⁵,Khachaturian Zaven⁵,Carrillo Maria⁵,Potter William⁵,Barnes Lisa⁵,Bernard Marie⁵,González Hector⁵,Ho Carole⁵,Hsiao John K.⁵,Jackson Jonathan⁵,Masliah Eliezer⁵,Masterman Donna⁵,Okonkwo Ozioma⁵,Perrin Richard⁵,Ryan Laurie⁵,Silverberg Nina⁵,Fleisher Adam⁵,Truran Sacrey Diana⁵,Fockler Juliet⁵,Conti Cat⁵,Veitch Dallas⁵,Neuhaus John⁵,Jin Chengshi⁵,Nosheny Rachel⁵,Ashford Miriam⁵,Flenniken Derek⁵,Kormos Adrienne⁵,Montine Tom⁵,Rafii Michael⁵,Raman Rema⁵,Jimenez Gustavo⁵,Donohue Michael⁵,Gessert Devon⁵,Salazar Jennifer⁵,Zimmerman Caileigh⁵,Cabrera Yuliana⁵,Walter Sarah⁵,Miller Garrett⁵,Coker Godfrey⁵,Clanton Taylor⁵,Hergesheimer Lindsey⁵,Smith Stephanie⁵,Adegoke Olusegun⁵,Mahboubi Payam⁵,Moore Shelley⁵,Pizzola Jeremy⁵,Shaffer Elizabeth⁵,Sloan Brittany⁵,Harvey Danielle⁵,Forghanian-Arani Arvin⁵,Borowski Bret⁵,Ward Chad⁵,Schwarz Christopher⁵,Jones David⁵,Gunter Jeff⁵,Kantarci Kejal⁵,Senjem Matthew⁵,Vemuri Prashanthi⁵,Reid Robert⁵,Fox Nick C.⁵,Malone Ian⁵,Thompson Paul⁵,Thomopoulos Sophia I.⁵,Nir Talia M.⁵,Jahanshad Neda⁵,DeCarli Charles⁵,Knaack Alexander⁵,Fletcher Evan⁵,Tosun-Turgut Duygu⁵,Rossi Chen Stephanie⁵,Choe Mark⁵,Crawford Karen⁵,Yushkevich Paul A.⁵,Das Sandhitsu⁵,Koeppe Robert A.⁵,Reiman Eric M.⁵,Chen Kewei⁵,Mathis Chet⁵,Landau Susan⁵,Cairns Nigel J.⁵,Householder Erin⁵,Franklin Erin⁵,Bernhardt Haley⁵,Taylor-Reinwald Lisa⁵,Korecka Magdalena⁵,Figurski Michal⁵,Neu Scott Neu⁵,Nho Kwangsik⁵,Risacher Shannon L.⁵,Apostolova Liana G.⁵,Shen Li⁵,Foroud Tatiana M.⁵,Nudelman Kelly⁵,Faber Kelley⁵,Wilmes Kristi⁵,Thal Leon⁵,Silbert Lisa C.⁵,Lind Betty⁵,Crissey Rachel⁵,Kaye Jeffrey A.⁵,Carter Raina⁵,Dolen Sara⁵,Quinn Joseph⁵,Schneider Lon S.⁵,Pawluczyk Sonia⁵,Becerra Mauricio⁵,Teodoro Liberty⁵,Dagerman Karen⁵,Spann Bryan M.⁵,Brewer James⁵,Vanderswag Helen⁵,Ziolkowski Jaimie⁵,Heidebrink Judith L.⁵,Zbizek-Nulph Lisa⁵,Lord Joanne L.⁵,Mason Sara S.⁵,Albers Colleen S.⁵,Knopman David⁵,Johnson Kris⁵,Villanueva-Meyer Javier⁵,Pavlik Valory⁵,Pacini Nathaniel⁵,Lamb Ashley⁵,Kass Joseph S. Kass⁵,Doody Rachelle S.⁵,Shibley Victoria Shibley⁵,Chowdhury Munir⁵,Rountree Susan⁵,Dang Mimi⁵,Stern Yaakov⁵,Honig Lawrence S.⁵,Mintz Akiva⁵,Ances Beau⁵,Winkfield David⁵,Carroll Maria⁵,Stobbs-Cucchi Georgia⁵,Oliver Angela⁵,Creech Mary L.⁵,Mintun Mark A.⁵,Schneider Stacy⁵,Geldmacher David⁵,Natelson Love Marissa⁵,Griffith Randall⁵,Clark David⁵,Brockington John⁵,Marson Daniel⁵,Grossman Hillel⁵,Goldstein Martin A.⁵,Greenber Jonathan⁵,Mitsis Effie⁵,Shah Raj C.⁵,Lamar Melissa⁵,Samuels Patricia⁵,Duara Ranjan⁵,Greig-Custo Maria T.⁵,Rodriguez Rosemarie⁵,Albert Marilyn⁵,Onyike Chiadi⁵,Farrington Leonie⁵,Rudow Scott⁵,Brichko Rottislav⁵,Kielb Stephanie⁵,Smith Amanda⁵,Ashok Raj Balebail⁵,Fargher Kristin⁵,Sadowski Martin⁵,Wisniewski Thomas⁵,Shulman Melanie⁵,Faustin Arline⁵,Rao Julia⁵,Castro Karen M.⁵,Ulysse Anaztasia⁵,Chen Shannon⁵,Sheikh Mohammed O.⁵,Singleton-Garvin Jamika⁵,Murali Doraiswamy P.⁵,Petrella Jeffrey R.⁵,James Olga⁵,Wong Terence Z.⁵,Borges-Neto Salvador⁵,Karlawish Jason H.⁵,Wolk David A.⁵,Vaishnavi Sanjeev⁵,Clark Christopher M.⁵,Arnold Steven E.⁵,Smith Charles D.⁵,Jicha Gregory A.⁵,El Khouli Riham⁵,Raslau Flavius D.⁵,Lopez Oscar L.⁵,Oakley MaryAnn⁵,Simpson Donna M.⁵,Porsteinsson Anton P.⁵,Martin Kim⁵,Kowalski Nancy⁵,Keltz Melanie⁵,Goldstein Bonnie S.⁵,Makino Kelly M.⁵,Seleem Ismail M.⁵,Brand Connie⁵,Thai Gaby⁵,Pierce Aimee⁵,Yanez Beatriz⁵,Sosa Elizabeth⁵,Witbracht Megan⁵,Kelley Brendan⁵,Nguyen Trung⁵,Womack Kyle⁵,Mathews Dana⁵,Quiceno Mary⁵,Levey Allan I.⁵,Lah James J.⁵,Hajjar Ihab⁵,Cellar Janet S.⁵,Burns Jeffrey M.⁵,Swerdlow Russell H.⁵,Brooks William M.⁵,Silverman Daniel H.S.⁵,Kremen Sarah⁵,Apostolova Liana⁵,Tingus Kathleen⁵,Lu Po H.⁵,Bartzokis George⁵,Woo Ellen⁵,Teng Edmond⁵,Graff-Radford Neill R⁵,Parfitt Francine⁵,Poki-Walker Kim⁵,Farlow Martin R.⁵,Hake Ann Marie⁵,Matthews Brandy R.⁵,Brosch Jared R.⁵,Herring Scott⁵,van Dyck Christopher H.⁵,Mecca Adam P.⁵,Good Susan P.⁵,MacAvoy Martha G.⁵,Carson Richard E.⁵,Varma Pradeep⁵,Chertkow Howard⁵,Vaitekunis Susan⁵,Hosein Chris⁵,Black Sandra⁵,Stefanovic Bojana⁵,Heyn Chris (Chinthaka)⁵,Robin Hsiung Ging-Yuek⁵,Kim Ellen⁵,Mudge Benita⁵,Sossi Vesna⁵,Feldman Howard⁵,Assaly Michele⁵,Finger Elizabeth⁵,Pasternak Stephen⁵,Rachinsky Irina⁵,Kertesz Andrew⁵,Drost Dick⁵,Rogers John⁵,Grant Ian⁵,Muse Brittanie⁵,Rogalski Emily⁵,Robson Jordan⁵,Marsel Mesulam M.⁵,Kerwin Diana⁵,Wu Chuang-Kuo⁵,Johnson Nancy⁵,Liposki Kristine⁵,Weintraub Sandra⁵,Bonakdarpour Borna⁵,Pomara Nunzio⁵,Hernando Raymundo⁵,Sarrael Antero⁵,Rosen Howard J.⁵,Miller Bruce L.⁵,Perry David⁵,Scott Turner Raymond⁵,Johnson Kathleen⁵,Reynolds Brigid⁵,McCann Kelly⁵,Poe Jessica⁵,Sperling Reisa A.⁵,Johnson Keith A.⁵,Marshall Gad A.⁵,Yesavage Jerome⁵,Taylor Joy L.⁵,Chao Steven⁵,Coleman Jaila⁵,White Jessica D.⁵,Lane Barton⁵,Rosen Allyson⁵,Tinklenberg Jared⁵,Belden Christine M.⁵,Atri Alireza⁵,Clark Kelly A.⁵,Zamrini Edward⁵,Sabbagh Marwan⁵,Killiany Ronald⁵,Stern Robert⁵,Mez Jesse⁵,Kowall Neil⁵,Budson Andrew E.⁵,Obisesan Thomas O.⁵,Ntekim Oyonumo E.⁵,Wolday Saba⁵,Khan Javed I.⁵,Nwulia Evaristus⁵,Nadarajah Sheeba⁵,Lerner Alan⁵,Ogrocki Paula⁵,Tatsuoka Curtis⁵,Fatica Parianne⁵,Maillard Pauline⁵,Olichney John⁵,Carmichael Owen⁵,Bates Vernice⁵,Capote Horacio⁵,Rainka Michelle⁵,Borrie Michael⁵,Lee T-Y⁵,Bartha Rob⁵,Johnson Sterling⁵,Asthana Sanjay⁵,Carlsson Cynthia M.⁵,Perrin Allison⁵,Burke Anna⁵,Scharre Douglas W.⁵,Kataki Maria⁵,Tarawneh Rawan⁵,Hart David⁵,Zimmerman Earl A.⁵,Celmins Dzintra⁵,Miller Delwyn D.⁵,Boles Laura L.⁵,Ekstam Smith Karen⁵,Koleva Hristina⁵,Shim Hyungsub⁵,Won Nam Ki⁵,Schultz Susan K.⁵,Williamson Jeff D.⁵,Craft Suzanne⁵,Cleveland Jo⁵,Yang Mia⁵,Sink Kaycee M.⁵,Ott Brian R.⁵,Drake Jonathan⁵,Tremont Geoffrey⁵,Daielllo Lori A.⁵,Ritter Aaron⁵,Bernick Charles⁵,Munic Donna⁵,O'Connelll Abigail⁵,Mintzer Jacobo⁵,Wiliams Arthur⁵,Masdeu Joseph⁵,Shi Jiong⁵,Garcia Angelica⁵,Newhouse Paul⁵,Potkin Steven⁵,Salloway Stephen⁵,Malloy Paul⁵,Correia Stephen⁵,Kittur Smita⁵,Pearlson Godfrey D.⁵,Blank Karen⁵,Anderson Karen⁵,Flashman Laura A.⁵,Seltzer Marc⁵,Hynes Mary L.⁵,Santulli Robert B.⁵,Relkin Norman⁵,Chiang Gloria⁵,Lin Michael⁵,Ravdin Lisa⁵,Lee Athena⁵,Neylan Thomas⁵,Grafman Jordan⁵,Danowski Sarah⁵,Nguyen-Barrera Catherine⁵,Hayes Jacqueline⁵,Finley Shannon⁵,Bernstein Matthew⁵,Foster Norm⁵,Kim Sungeun⁵,Sood Ajay⁵,Blanchard Kimberly S.⁵,Arfanakis Konstantinos⁵,Fleischman Debra⁵,Varon Daniel⁵,Reist Christopher⁵,Sadowsky Carl⁵,Martinez Walter⁵,Villena Teresa⁵,Peskind Elaine R.⁵,Petrie Eric C.⁵,Li Gail⁵,Mackin Scott⁵,Drake Erin⁵,Nelson Craig⁵,Bikford David⁵,Butters Meryl⁵,Zmuda Michelle⁵,Reyes Denise⁵,Ho Au Yiu⁵,Scherer Kelly⁵,Catalinotto Daniel⁵,Stark Samuel⁵,Ong Elise⁵,Fernandez Dariella⁵,

Affiliation:

1. Division of Psychiatry, University College London, London, United Kingdom

2. Dementia Research Centre, University College London, London, United Kingdom

3. UCL Institute of Cognitive Neuroscience and UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

4. Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom

5. for the Alzheimer’s Disease Neuroimaging Initiative

Abstract

ImportanceUnderstanding the mechanisms of delusion formation in Alzheimer disease (AD) could inform the development of therapeutic interventions. It has been suggested that delusions arise as a consequence of false memories.ObjectiveTo investigate whether delusions in AD are associated with false recognition, and whether higher rates of false recognition and the presence of delusions are associated with lower regional brain volumes in the same brain regions.Design, Setting, and ParticipantsSince the Alzheimer’s Disease Neuroimaging Initiative (ADNI) launched in 2004, it has amassed an archive of longitudinal behavioral and biomarker data. This cross-sectional study used data downloaded in 2020 from ADNI participants with an AD diagnosis at baseline or follow-up. Data analysis was performed between June 24, 2020, and September 21, 2021.ExposureEnrollment in the ADNI.Main Outcomes and MeasuresThe main outcomes included false recognition, measured with the 13-item Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog 13) and the Rey Auditory Verbal Learning Test (RAVLT) and volume of brain regions corrected for total intracranial volume. Behavioral data were compared for individuals with delusions in AD and those without using independent-samples t tests or Mann-Whitney nonparametric tests. Significant findings were further explored using binary logistic regression modeling. For neuroimaging data region of interest analyses using t tests, Poisson regression modeling or binary logistic regression modeling and further exploratory, whole-brain voxel-based morphometry analyses were carried out to explore the association between regional brain volume and false recognition or presence of delusions.ResultsOf the 2248 individuals in the ADNI database, 728 met the inclusion criteria and were included in this study. There were 317 (43.5%) women and 411 (56.5%) men. Their mean (SD) age was 74.8 (7.4) years. The 42 participants with delusions at baseline had higher rates of false recognition on the ADAS-Cog 13 (median score, 3; IQR, 1 to 6) compared with the 549 control participants (median score, 2; IQR, 0 to 4; U = 9398.5; P = .04). False recognition was not associated with the presence of delusions when confounding variables were included in binary logistic regression models. An ADAS-Cog 13 false recognition score was inversely associated with left hippocampal volume (odds ratio [OR], 0.91 [95% CI, 0.88-0.94], P &lt; .001), right hippocampal volume (0.94 [0.92-0.97], P &lt; .001), left entorhinal cortex volume (0.94 [0.91-0.97], P &lt; .001), left parahippocampal gyrus volume (0.93 [0.91-0.96], P &lt; .001), and left fusiform gyrus volume (0.97 [0.96-0.99], P &lt; .001). There was no overlap between locations associated with false recognition and those associated with delusions.Conclusions and RelevanceIn this cross-sectional study, false memories were not associated with the presence of delusions after accounting for confounding variables, and no indication for overlap of neural networks for false memories and delusions was observed on volumetric neuroimaging. These findings suggest that delusions in AD do not arise as a direct consequence of misremembering, lending weight to ongoing attempts to delineate specific therapeutic targets for treatment of psychosis.

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health

Link

https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2804863/jamapsychiatry_mclachlan_2023_oi_230026_1687981917.62007.pdf

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