Why Hippocampal Glutamate Levels Are Elevated in Schizophrenia-Reference-Cited by-同舟云学术

Why Hippocampal Glutamate Levels Are Elevated in Schizophrenia

Published:2023-03-01 Issue:3 Volume:80 Page:274
ISSN:2168-622X
Container-title:JAMA Psychiatry
language:en
Short-container-title:JAMA Psychiatry

Author:

Guo Jia¹,Rothman Douglas L.²,Small Scott A.¹

Affiliation:

1. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Mortimer B. Zuckerman Mind Brain Behavior Institute, Departments of Neurology and Psychiatry, Columbia University, New York, New York

2. Yale University School of Medicine, Department of Radiology and Biomedical Imaging and Department of Biomedical Engineering, Yale University, New Haven, Connecticut

Abstract

This article discusses why glutamate levels are abnormally elevated in the hippocampus of patients with schizophrenia and related disorders.

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health

Link

https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2800312/jamapsychiatry_guo_2023_np_220001_1677529734.73005.pdf

Reference10 articles.

1. Rare coding variants in ten genes confer substantial risk for schizophrenia.;Singh;Nature,2022

2. Mapping genomic loci implicates genes and synaptic biology in schizophrenia.;Trubetskoy;Nature,2022

3. A pathophysiological framework of hippocampal dysfunction in ageing and disease.;Small;Nat Rev Neurosci,2011

4. Increased hippocampal CA1 cerebral blood volume in schizophrenia.;Talati;Neuroimage Clin,2014

5. Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level.;Merritt;JAMA Psychiatry,2021

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