Do Not Rule Out Double-blind Placebo Run-in Periods for Randomized Clinical Trials
Author:
Affiliation:
1. Signant Health, Boston, Massachusetts
Publisher
American Medical Association (AMA)
Subject
Psychiatry and Mental health
Link
https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2789696/jamapsychiatry_targum_2022_le_220001_1648226536.36656.pdf
Reference5 articles.
1. Association of single-blind placebo run-in periods with the placebo response in randomized clinical trials of antidepressants: a systematic review and meta-analysis.;Scott;JAMA Psychiatry,2022
2. The problem of the placebo response in clinical trials for psychiatric disorders: culprits, possible remedies, and a novel study design approach.;Fava;Psychother Psychosom,2003
3. The double-blind variable placebo lead-in period: results from two antidepressant clinical trials.;Faries;J Clin Psychopharmacol,2001
4. Early score fluctuation and placebo response in a study of major depressive disorder.;Targum;J Psychiatr Res,2020
5. Penny-wise and pound-foolish: the impact of measurement error on sample size requirements in clinical trials.;Perkins;Biol Psychiatry,2000
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