Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants

Author:

Bikdeli Behnood1234,Zahedi Tajrishi Farbod5,Sadeghipour Parham67,Talasaz Azita H.89,Fanikos John10,Lippi Giuseppe11,Siegal Deborah M.12,Eikelboom John W.13,Monreal Manuel14,Jimenez David15,Connors Jean M.16,Ageno Walter17,Barnes Geoffrey D.18,Piazza Gregory12,Angiolillo Dominick J.19,Parikh Sahil A.420,Kirtane Ajay J.420,Lopes Renato D.2122,Bhatt Deepak L.1,Weitz Jeffrey I.2324,Mehran Roxana25,Krumholz Harlan M.32627,Goldhaber Samuel Z.12,Lip Gregory Y. H.2829

Affiliation:

1. Cardiovascular Medicine Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

2. Thrombosis Research Group, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

3. Yale New Haven Hospital/Yale Center for Outcomes Research and Evaluation, New Haven, Connecticut

4. Cardiovascular Research Foundation, New York, New York

5. Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

6. Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

7. Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

8. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

9. Virginia Commonwealth University, Richmond

10. Department of Pharmacy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

11. Section of Clinical Biochemistry, University of Verona, Verona, Italy

12. Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

13. Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada

14. Department of Internal Medicine, Hospital Universitari Germans Trials i Pujol, Universidad Católica San Antonio de Murcia, Barcelona, Spain

15. Respiratory Department, Hospital Ramón y Cajal and Medicine Department, Universidad de Alcalá (Instituto de Ramón y Cajal de Investigación Sanitaria), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Spain

16. Hematology Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

17. Department of Medicine and Surgery, University of Insubria, Varese, Italy

18. Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor

19. Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida

20. Division of Cardiology, New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York

21. Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina

22. Brazilian Clinical Research Institute, São Paulo, Brazil

23. McMaster University, Hamilton, Ontario, Canada

24. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

25. Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York

26. Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut

27. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut

28. Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom

29. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

Publisher

American Medical Association (AMA)

Subject

Cardiology and Cardiovascular Medicine

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