Affiliation:
1. Federal State Educational Institution of Higher Professional Education Lomonosov Moscow State University; Russian Academy of Sciences
2. FSBI “Zakusov Institute of Pharmacology”
3. Federal State Educational Institution of Higher Professional Education Lomonosov Moscow State University
Abstract
Background. The dipeptide drug Noopept, created at the Zakusov Institute of Pharmacology, has a wide range of pharmacological actions, including cytoprotective one. In connection with the increasing pollution of the environment, it is urgent to identify the protective properties of drugs with a negative effect of heavy metal compounds on the live system. The aim of the present study was to investigate the cytoprotective effects of Noopept under toxicity induced by heavy metal compounds using ciliates Paramecium caudatum as a test object. Methods. The ciliates Paramecium caudatum were exposed to 4 salts of heavy metals: cadmium chloride, lead acetate, copper sulfate, zinc sulfate, as well as nanoparticles of copper oxide and zinc oxide. Noopept was added to the medium with the experimental cells 30 min before the introduction of damaging agents, at concentrations of 0.01–10 μM. Results. It was found that the presence of metal salts in the medium significantly reduced the number Paramecium сaudatum cells, depending on the time of exposure. Noopept at all studied concentrations reduced cell death, while the maximum intensity of the effect was observed at a concentration of 1 μM. Conclusions. The results obtained make it possible to supplement data on the wide spectrum of Noopept's action.
Subject
Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science
Reference20 articles.
1. Gudasheva T. A., Voronina T. A., Ostrovskaya R. U. et al. Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides. European Journal of Medicinal Chemistry. 1996; 31 (1996): 151–157. DOI: 10.1016/0223-5234(96)80448-X.
2. Patent RF na izobretenie № 2119496 / 27. 09. 98. Byul. № 27. / Seredenin S. B. [i dr.] Proizvodnye N-atsilprolildipeptidov. [Patent RUS № 2119496 / 27. 09. 98. Byul. №27 / Seredenin S. B., Voronina T. A., Gudasheva T. A. et al. Proizvodnie N-acilprolildipeptidov. (In Russ).]. Dostupno po: http://allpatents.ru/patent/2119496.html. Ssylka aktivna na 01. 11. 2021.
3. Seredenin S. B., Voronina T. A., Gudasheva T. A. et al., inventors; Saegis Pharmaceuticals Inc., assignee. Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects. United States patent US. 1995 Aug 8.
4. Zainullina L. F. Nootropnoe sredstvo Noopept aktiviruet transkriptsionnyi faktor HIF-1 / L. F. Zainullina [i dr.] // Doklady Rossiiskoi akademii nauk. Nauki o zhizni. – 2020. – 494 (1): 527–531. DOI: 10.31857/S2686738920050248. [Zainullina L. F., Ivanova T. V., Sadovnikov S. V. et al. Cognitive Enhancer Noopept Activates Transcription Factor HIF-1. Dokl Biochem Biophys. 2020; 494 (1): 256–260. (In Russ).]. DOI:10.1134/S1607672920050129.
5. Pivovarov A. S. Vliyaniya Noopepta i piratsetama na depressiyu vyzvannogo atsetilkholinom toka v komandnykh neironakh vinogradnoi ulitki / A. S. Pivovarov, G. B. Murzina, N. V. Vasil'eva // Zhurnal vysshei nervnoi deyatel'nosti im. I. P. Pavlova. – 2020. – 70 (1): 125–132. [Influence of Noopept and piracetam on acetylcholin-induced input currentin helix lucorum neurons. I. P. Pavlov Journal of Higher Nervous Activity. 2020; 70 (1): 125–132.