Pharmacokinetics of a potential antiepileptic drug GIZh-298-Reference-Cited by-同舟云学术

Pharmacokinetics of a potential antiepileptic drug GIZh-298

Published:2024-08-08 Issue:2 Volume: Page:57-61
ISSN:2686-8830
Container-title:Pharmacokinetics and Pharmacodynamics
language:
Short-container-title:Fk&Fd

Author:

Kolyvanov G. B.¹^ORCID,Litvin A. A.¹^ORCID,Kravtsova O. Yu.¹^ORCID,Gribakina O. G.¹^ORCID,Zherdev V. P.¹^ORCID

Affiliation:

1. Federal research center for innovator and emerging biomedical and pharmaceutical technologies

Abstract

GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration.Methods. The study was conducted on outbred male rats. The concentrations of GIZh-298 in the blood plasma were determined by HPLC with mass-spectrometric detection. Pharmacokinetic parameters were evaluated using a model-independent method.Results. After single and multiple (4 times with a dosage interval of 3 hours) intragastric administrations at 60 mg/kg dose, the test substance in the blood plasma was determined for 4 hours. The mode of administration of GIZh-298 did not affect the value of its half-life and the mean residence time. It has been established that GIZh-298 accumulates in the rats.

Publisher

Publishing House OKI

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