Affiliation:
1. FSBI “Zakusov Institute of Pharmacology”
Abstract
Thе article represents a review of our own researches, which describes the design, synthesis and pharmacological properties of linear substituted glyproline GZK-111, a potential drug for the complex treatment of psychiatric pathologies, including anxiety, depressive disorders, and cognitive impairment. The relationship between structure and activity in a series of this glyproline analogs is described. The experimental evidence of the GZK-111 ability to metabolized with the formation of cycloprolylglycine, which is identical to the endogenous cyclic dipeptide, is presented. The data on toxicological and pharmacokinetic studies of GZK-111 are presented.
Subject
Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science
Reference34 articles.
1. Гудашева Т.А., Островская Р.У., Максимова Ф.В. и др. Топологические аналоги пирацетама на основе пролина и их ноотропная активность. Химико-фармацевтический журнал. 1989;23(3):276–281.
2. Gudasheva TA, Boyko SS, Akparov VKh, Ostrovskaya RU, Skoldinov SP, Rozantsev GG, Voronina TA, Zherdev VP, Seredenin SB. Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain. FEBS Letters. 1996;391(1-2):149–152. DOI: 10.1016/0014-5793(96)00722-3.
3. Tran LH, inventor; Neurobiomed Corp, assignee. Neuroprotection and neuroegenisis by administering cyclic prolyl glycine. United States patent US 7232798B2. 2007.
4. Guan J, Mathai S, Harris P, Wen J-Y, Zhang R, Brimble M, Gluckman P. Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia– ischemia in adult rats. Neuropharmacology. 2007;53(6):749–762. DOI: 10.1016/j.neuropharm.2007.08.010.
5. Gudasheva TA, Ostrovskaya RU, Trofimov SS, et al. New Endogenous Dipeptide Cycloprolyl-Glycine Is Similar To Piracetam By Its Mnemotropic Selectivity. Bulletin of experimental biology and medicine. 1999;128(4):411–413. (In Russ).