Change of opinion on the use of hydroxychloroquine for COVID-19 treatment and prevention

Author:

Mirzaev K. B.1ORCID,Sychev D. A.1ORCID

Affiliation:

1. Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

Abstract

The use of hydroxychloroquine for COVID-19 treatment and prevention should be restricted in both out- and inpatient settings due to the lack of evidence for effectiveness and unfavorable safety profile.

Publisher

Publishing House OKI

Subject

General Medicine

Reference7 articles.

1. Gautret P et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Jul;56(1):105949. DOI: 10.1016/j.ijantimicag.2020.105949

2. Yao X et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Jul 28;71(15):732-739. DOI: 10.1093/cid/ciaa237

3. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments

4. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautionsagainst-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospitalsetting-or

5. https://www.tropmedres.ac/covid-19/copcov/copcov-key-messages

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