Affiliation:
1. Institute of Experimental Medicine
2. Saint-Petersburg Pasteur Institute of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Abstract
The wide prevalence of inflammatory vaginal diseases in women of different ages, a significant deterioration in the quality of life due to their presence, as well as an adverse effect on conception and the course of pregnancy make the search for more efficient and safe therapy of vaginitis an urgent issue. The article presents the results of experimental staphylococcal vaginitis treatment with probiotics and autoprobiotics in rat models, including hormonized animals after ovariectomy. The effectiveness of topical application of the probiotic strain E. faecium L3 in rats has been confirmed. The probiotic proved to be effective both in rats with a hormonized cycle and in rats with preserved ovaries. Among the tested autoprobiotic and homologous (rat) strains, the elimination of staphylococci occurred faster after the introduction of bifidobacterial. However, lactobacilli are more reliable in protection against the recurrence of infection. At the same time, homologous strains of both lactobacilli and bifidobacteria contribute to faster elimination of the pathogen compared to autostamps.
Subject
Infectious Diseases,Microbiology (medical),General Medicine,Microbiology
Reference27 articles.
1. Ling Z., Liu X., Chen X., Zhu H., Nelson K., Xia Y., Li L. et al. Diversity of cervicovaginal microbiota associated with female lower genital tract infections. Microbial Ecol. 2011; 61 (3): 704–714. doi: 10.1007/s00248-011-9813-z.
2. Rishhuk S., Punchenko O.,Malysheva A. Endogennaya mikrobiota vlagalishha i eyo regulyacziya. Byulleten` Orenburgskogo Nauchnogo Czentra. 2013; 4 (15). (in Russian)
3. Punchenko O., Bereznitskaya E, Ermolenko E. Female genital microbiota: health, pathology, ways of correction. Akusherstvo i Ginekologiya. 2021; 3: 18–24. https://doi.org/10.18565/aig.2021.3.18-24. (in Russian)
4. Buck G. Diversity of the human vaginal microbiome. J Bacteriol Parasitol. 2014; 05 (04): 5.
5. Damarad A.L., Gonchar O.A. Diagnostika bakterial'nogo vaginoza i aerobnogo vaginita metodom amplifikacii nukleinovyh kislot v rezhime real'nogo vremeni (PCR). Dermatovenerologiya. Kosmetologiya. 2016; 2 (1): 60–65. (in Russian)
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