The Issue of Post-COVID Syndrome in Children and Adolescents: Approaches to Terminology, Pathogenesis, Clinical Manifestations, Diagnosis, and Treatment

Abstract

The article discusses the issues of terminology, epidemiology, etiopathogenesis, clinical manifestations, approaches to the diagnosis and treatment of post-covid syndrome (PCS). It has been shown that the incidence of PCS in people who had COVID-19 is 10–35%; there are no generally accepted approaches to defining the term PCS. Clinical manifestations of PCS include more than 50 symptoms that occur in both children and adults, regardless of their place of residence. The damage caused by metabolites of the systemic inflammatory response of the central nervous system with the formation of a syndrome of autonomic dysfunction,  cognitive  impairment,  and affective disorders is of critical importance  in the genesis of PCS.  Antipsychotics, antidepressants, and benzodiazepine drugs are used in the correction of PCS. However, they have limitations, in particular — when used in children with comorbid disorders. The use of aminoacetic acid (glycine), which has a wide range of safety,anxiolytic, anti-inflammatory, and nootropic effects in the correction of PCS, can become an effective therapeutic strategy.