Synthesis n-oxides of pyridylacethylene amines based on 2-methyl-5-ethynylpyridine-Reference-Cited by-同舟云学术

Synthesis n-oxides of pyridylacethylene amines based on 2-methyl-5-ethynylpyridine

Published:2021-04-25 Issue: Volume: Page:48-53
ISSN:2181-1121
Container-title:CHEMISTRY AND CHEMICAL ENGINEERING
language:en
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Abstract

The aim of this work is to study the reaction of 2-methyl-5-ethynylpyridine N-oxide with some aliphatic and aromatic amines to obtain N-oxides of pyridylacetylenic amines. 2-Methyl-5-ethylpyridine converted to 2-methyl-5-vinylpyridine by dehydrogenation, and 2-methyl-5-ethynylpyridine obtained by bromination and dehydrobromination. 2-methyl-5-ethynylpyridine N-oxide synthesized by oxidation of 2-methyl-5-ethynylpyridine with perhydrol in acetic anhydride. The synthesis of N-oxides of pyridylacetylenic amines by the Mannich reaction carried out. The effect of the solvents: methanol, ethanol and n-dioxane, the catalyst, and the reaction time on the yield of the final product studied. The structure and composition of the synthesized PAA N-oxides were established using IR and PMR spectroscopy.

Publisher

Uzbekistan Research Online

Subject

General Medicine

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