Abstract
The aim of the study is to develop a technology for obtaining a food additive for the extract of the pulp of bitter watermelon - Citrullus colocynthis, introduced in Uzbekistan as a hypoglycemic agent. Pharmacological studies have shown the presence of a hypoglycemic effect for aqueous and alcoholic extracts and 2-O-β-glucopyranosyl-cucurbitacin E in rats with alloxan diabetes mellitus. Cucurbitacins were isolated from the extract - cucurbitacin E, 2-O-β-glucopyranosyl-cucurbitacin E and other bioactive substances.
The food supplement obtained from bitter watermelon (Citrullus colocynthis (family Cucurbitaceae)) according to the developed technology showed a higher hypoglycemic activity compared to the drug arfazetin.
Publisher
Uzbekistan Research Online
Reference21 articles.
1. Benariba N., Djaziri R., Bellakhdar W., Belkacem N., Kadiata M., Malaisse W., Sener A. Phytochemical screening and free radical scavenging activity of Citrullus colocynthis seeds extracts Asian Pacific. J. Trop. Biomed., 2013, vol. 3, no. 1, pp. 35-40.
2. Borhade P., Deshmufch T., Patil V., Khandelwal К. Review on Citrullus coloajnthis. Int. J. Phar. Chem., 2013, vol. 3, no. 1, pp. 46-53.
3. Yankov L.K., Hussein S.M. Fatty acid from the oil of the seeds of Citrullus colocynthis. Dokl. Bolg. Akad. Nouk, 1975, vol. 28, pp. 209-212.
4. Hatam N.A.R., Donald A.W., Yousif N.J. Cucurbitacin glycosides from Citrullus colocynthis. Phytochemistry, 1989, vol. 59, pp. 1268-1271.
5. Maatooq G.T., El-Sharkawy S.H., Afifi M.S., Rosazza J.P.N. C-phydroxybenzoyl glycoflavones from Citrullus colocynthis. Phytochemistry, 1997, vol. 44. 187-190.