Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

Author:

Leenders Marika12,Verdijk Lex B.12,van der Hoeven Letty12,van Kranenburg Janneau12,Hartgens Fred3,Wodzig Will K. W. H.4,Saris Wim H. M.2,van Loon Luc J. C.12

Affiliation:

1. Top Institute Food and Nutrition, 6700 AN Wageningen, The Netherlands

2. Department of Human Movement Sciences and Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands

3. Departments of Epidemiology and Surgery, Research School CAPHRI, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands

4. Department of Clinical Chemistry, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference39 articles.

1. Functional and metabolic consequences of sarcopenia;Evans;J Nutr.,1997

2. Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study;Park;Diabetes.,2006

3. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle;Cuthbertson;FASEB J.,2005

4. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly;Volpi;J Clin Endocrinol Metab.,2000

5. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly;Katsanos;Am J Physiol Endocrinol Metab.,2006

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