Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults

Author:

Philip Dana1,Buch Assaf1,Moorthy Denish2,Scott Tammy M2,Parnell Laurence D3,Lai Chao-Qiang3,Ordovás José M3,Selhub Jacob4,Rosenberg Irwin H2,Tucker Katherine L56,Troen Aron M12ORCID

Affiliation:

1. Nutrition and Brain Health Laboratory, Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

2. Neuroscience and Aging Laboratory

3. Nutritional Genomics Laboratory

4. Vitamin Metabolism Laboratory

5. Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA

6. Department of Clinical Laboratory and Nutritional Sciences at University of Massachusetts, Lowell, MA

Funder

Ross Institute of Aging pilot grant

Israel Science Foundation

Marie Curie Cancer Care

NIH

NCRR

USDA

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference73 articles.

1. Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly;Dimopoulos;In Vivo,2006

2. Correlation of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population;Dimopoulos;Clin Biochem,2007

3. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging;Kado;Am J Med,2005

4. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia;Quadri;Am J Clin Nutr,2004

5. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification;Ramos;Am J Clin Nutr,2004

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