The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake

Author:

Ozaki Mari1,Molloy Anne M2,Mills James L3,Fan Ruzong3,Wang Yifan3,Gibney Eileen R4,Shane Barry5,Brody Lawrence C6,Parle-McDermott Anne1

Affiliation:

1. Nutritional Genomics Group, School of Biotechnology, Dublin City University, Dublin, Ireland

2. Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland

3. Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Human Genome Research Institute, NIH, Bethesda, MD

4. Institute of Food and Health, University College Dublin, Dublin, Ireland

5. University of California, Berkeley, Berkeley, CA

6. Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD

Funder

Health Research Board

NICHD (National Institute of Child Health and Human Development)

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference33 articles.

1. A novel single-nucleotide polymorphism in the 3′-untranslated region of the human dihydrofolate reductase gene with enhanced expression;Goto;Clin Cancer Res,2001

2. Folate pathway enzyme gene polymorphisms and the efficacy and toxicity of methotrexate in psoriatic arthritis;Chandran;J Rheumatol,2010

3. Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians;Sharma;Pharmacogenet Genomics,2009

4. Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels;Gellekink;Eur J Hum Genet,2007

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