Affiliation:
1. Departamento de Agronomía, Universidad Nacional del Sur, Bahía Blanca, Argentina, Socia POA Núm. 19943. Titular del criadero Vom Alderchen (Reg. 9689)
Abstract
Canine hip dysplasia (CHD) is a progressive and disabling disorder in large dog breeds, such as the German Shepherd dog. Breeding sires and dams free of dysplasia is the only way to reduce its incidence. Several diagnostic methods have been developed based on radiographic examination, on the basis of which dogs are selected for breeding. CHD has a polygenic hereditary basis and environmental influence, with a median to low heritability (ca. 0,20 to 0,40), so the progress in phenotypic selection has been slow. In Argentina, the prevalence of dysplasia in German Shepherd dogs remains high (> 25%) and it is impossible to predict its incidence in the offspring of the breeding stock. Some countries have implemented a selection based on the estimated breeding value, obtaining an important advance. Genome-wide association studies have revealed numerous CHD-associated markers and several candidate genes have been found that point to the possibility of implementing genomic selection in the near future.
Key words: canine hip dysplasia, German Shepherd dog, phenotypic selection, genomic selection, estimated breeding value
Publisher
Sociedad Argentina de Genetica
Subject
Genetics (clinical),Genetics,Applied Microbiology and Biotechnology,Biotechnology