Study on VDR Polymorphism Influence in Associating with Diabetes Mellitus
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Published:2021-01-01
Issue:1
Volume:26
Page:2249-2254
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ISSN:1224-5984
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Container-title:Romanian Biotechnological Letters
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language:
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Short-container-title:Rom Biotechnol Lett.
Author:
BERCA LAVINIA-MARIANA,MOSOIU CLAUDIA-ELENA,NICA SILVIA,APOSTOL POMPILIA PETRUȚA,NICA REMUS,CIMPONERIU DANUT
Abstract
The aim of this study was to evaluate the association between vitamin D receptor, IL6 polymorphisms and DM. DNA was used to genotype the VDR FokI (rs2228570), TaqI (rs731236) and ApaI (rs7975232) polymorphisms by PCR RFLP and IL6 G-174C (rs1800795) by tetra-primer ARMS PCR. The presence of torque teno viruses DNA was assessed with heminested-PCR. For this study T1DM (n = 107) and T2DM (n = 124) patients and matched clinically healthy subjects (n = 200) were recruited. T1DM patients have a tendency to be more frequent carriers of the C allele and TTV infection than controls (OR = 1.9, p = 0.03). VDR tt genotype and VDR “FAt” haplotype are risk factors for T1DM. VDR “fAt” haplotype may increases the risk for T2DM. These associations were not changed after exclusion from statistical analysis of patients with hypertension, myocardial infarction, stroke or breast cancer.
Publisher
Digital ProScholar Media
Subject
Agronomy and Crop Science,Genetics,Applied Microbiology and Biotechnology,Biotechnology