Investigation of the Physiological and Histopathological Effects of Omega Acids (3, 6, 9) and Stearic Acid on Rats in Ischemia Reperfusion-Reference-Cited by-同舟云学术

Investigation of the Physiological and Histopathological Effects of Omega Acids (3, 6, 9) and Stearic Acid on Rats in Ischemia Reperfusion

Published:2024-07-01 Issue:1 Volume:12 Page:12-23
ISSN:2147-7930
Container-title:Muş Alparslan Üniversitesi Fen Bilimleri Dergisi
language:
Short-container-title:

Author:

Karahan Tuğba¹^ORCID,Arıhan Okan²^ORCID,Oto Gokhan³^ORCID,Yildirim Serkan⁴^ORCID,Kömüroğlu Ahmet Ufuk¹^ORCID,Karahan Fatih⁵^ORCID

Affiliation:

1. YÜZÜNCÜ YIL ÜNİVERSİTESİ, VAN SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU

2. HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.

3. YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ

4. ATATÜRK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ

5. YUZUNCU YIL UNIVERSITY, FACULTY OF SCIENCE

Abstract

Ischemia causes reversible or irreversible cell or tissue damage due to insufficient blood flow to the organ or tissue. In this study, our aim is to investigate the protective effect of omega 3, 6 9 and stearic acid application before ischemia reperfusion injury in the leg muscles. For this purpose, 70 female albino rats were divided into 10 groups. The study continued at the same dose for 14 days. In addition, these fatty acids were given to other groups without ischemia-reperfusion. After the application different faty acid, blood biochemical parameters of different fatty acids, oxidative stress parameters and histopathology of tissues (liver, kidney, muscle) were examined in rats. As a result, it was observed that omega 9 fatty acid has better protective properties compared to other omega fatty acids and stearic acid in terms of histopathological properties and oxidative stress index. Additionally, other fatty acids and stearic acid provided some degree of protection against the deleterious effects of ischemia-reperfusion

Funder

yüzüncü Yıl Üniversitesi BAP birimi

Publisher

Mus Alparslan Universitesi Fen Bilimleri Dergisi

Reference53 articles.

1. [1] Cotran R.S., Kumar V., Robbins S.L. Temel patoloji. Çevikbaş U (Çeviren) 5. Baskı. İstanbul: Nobel ve Yüce; 1995.

2. [2] Herbert K.J., Hickey M.J., Lepore D.A., Knight K.R., Morrison W.A., Stewart A.G. Effects of the endothelin receptor antagonist Bosentan on ischaemia/reperfusion injury in rat skeletal muscle, Eur J Pharmacol, 424:59-67, 2001.

3. [3] Welbourn C.R., Goldman G., Paterson I.S., Valeri C.R., Shepro D., Hechtman H.B. Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil, Br J Surg, 78:651-5, 1991.

4. [4] Petrasek P.F., Walker P.M. A clinically relevant small-animal model of skeletal muscle ischemia reperfusion injury, J Invest Surg, 7: 27–38, 1994.

5. [5] Olguner C., Koca U., Kar A., Karci A., Ifllekel H., Canyilmaz M., Mavioĝlu O., Kizildaĝ S., Unlü A., Elar Z. Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilPateral lower limb ischemia reperfusion, Acta Anaesthesiol Scand, 50: 150-5, 2006.