THE EFFECTS OF INSULIN, RESERPINE AND CHOLINE 2:6-XYLYLETHER BROMIDE ON THE ADRENAL MEDULLA AND ON MEDULLARY AUTOGRAFTS IN THE RAT

Abstract

SUMMARY The adrenaline and noradrenaline content of the adrenal medulla and medullary implants has been assessed by histochemical and assay techniques after the injection of insulin, reserpine, and choline 2:6-xylylether bromide (TM10) into Wistar and Sprague-Dawley strain rats. Insulin hypoglycaemia is without effect on implanted chromaffin cells, but reduces the adrenaline content of the intact adrenal. Reserpine reduces the catechol amine content of both normal and grafted chromaffin cells. TM10, given as a single intravenous injection, has no effect on either normal or implanted chromaffin cells.