HUMAN URINARY GONADOTROPHINS

Abstract

SUMMARY Various human urinary gonadotrophins and pregnant mares' serum (PMS) frequently gave log dose-log response lines of divergent slope in the assay of Claringbold & Lamond [1957]. This is contrary to their findings and shows dissimilarity in the early action of different gonadotrophins. There were marked differences in the response of mice from different colonies to PMS and human chorionic gonadotrophin (HCG). Results by the method of Claringbold & Lamond contrasted more sharply with those of an 'HCG-augmentation' assay for follicle-stimulating hormone than did results of a 72 hr assay using uterine response.