Author:
ARTETA J. L.,KÖNIG C.,CARBALLIDO A.
Abstract
SUMMARY
The injection of 2–3 g/kg body weight of glucose inhibits the diabetogenic action of subsequently injected alloxan (65 mg/kg) and protects against the lethal effect of 100–120 mg alloxan/kg in the dog. Protection is less marked when glucose and alloxan are administered together.
Insulin injections in doses sufficient to induce severe hypoglycaemia sensitize the dogs in such a manner as to convert non-diabetogenic doses of alloxan (30 mg/kg body weight) into diabetogenic ones.
Female dogs are less sensitive to the action of insulin than males. Of a total of seven males and five females, all the males, but only one female, became diabetic.
It is suggested that the concentration of glucose within and surrounding the β-cells of the pancreas regulates the degree of sensitivity of these cells to alloxan.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
11 articles.
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