URINARY EXCRETION OF OESTRONE, OESTRADIOL-17β AND OESTRIOL IN PATIENTS WITH CHRONIC LIVER DAMAGE

Author:

CAMERON C. B.

Abstract

SUMMARY The urinary excretion of oestrone, oestradiol-17β and oestriol has been estimated by a chemical technique in nine men and three women with chronic liver disease. Combined oestrone, oestradiol and oestriol excretion was above normal limits in only two patients, both men. One excreted more than normal amounts of all three oestrogens; the other excreted more oestriol only. In addition, four men and one woman excreted more oestriol than normal, but this was not sufficient to increase the combined excretion of these three oestrogens beyond levels found in healthy controls. These findings are contrary to many published conclusions based on bioassay. Oestrogen excretion has been contrasted with the clinical findings. There was no correlation between increased oestrogen excretion and gynaecomastia. There was, however, a suggestive association of increased oestriol excretion, testicular atrophy, and a history of alcoholism. No association was established between an increased excretion of any oestrogen and the presence of ascites, jaundice, spider naevi and palmar erythema. Some implications of these findings are discussed.

Publisher

Bioscientifica

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Cited by 46 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Estrogen and androgen dynamics in liver disease;Journal of Endocrinological Investigation;1984-12

2. The effect of oral contraceptives on reproductive function during semichronic exposure to ethanol by the female rat;General Pharmacology: The Vascular System;1982-01

3. Bindungskapazität von sexualhormon- und corticosteroidbindendem Globulin im Serum bei Männern mit Lebercirrhose;Clinical Chemistry and Laboratory Medicine;1980

4. 4 The effect of chronic alcohol abuse on sexual function;Clinics in Endocrinology and Metabolism;1979-11

5. Alcohol-Induced Ovarian Failure in the Rat;Journal of Clinical Investigation;1978-03-01

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