Abstract
ABSTRACT
Luteal oxytocin-containing secretory granules have been isolated and characterized in terms of their physicochemical parameters. The isopynic sedimentation density (1·03 ±0·003 g/ml) and sedimentation coefficient (1670 S, 0·32 mol sucrose/l, 4 °C) of these granules have been estimated. Based upon these estimates, the average vesicle diameter (258 ± 17 nm) and vesicle weight (9·92 ±0·67 fg/vesicle) were calculated. The exchangeable water content (58·2%) of these granules was determined using density gradients prepared with deuterium oxide. Luteal oxytocin-containing granules displayed similar physicochemical characteristics to those reported for neurohypophysial peptide-containing granules, with the exception of particle size. Luteal granules were 1·3 times greater in diameter than neurohypophysial granules.
J. Endocr. (1988) 116, 267–272
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
3 articles.
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