Author:
Boer G. J.,Kruisbrink J.,van Pelt-Heerschap H.
Abstract
A long-lasting and constant release of vasopressin in serum solution (in vitro) for periods up to 50 days can be obtained by the use of small-diameter microporous Accurel polypropylene tubing, filled with vasopressin and covered with collodion. The potency of the preparation is shown in vivo after subcutaneous implantation in the adult vasopressin-deficient Brattleboro rat, for which normal levels of urine production and osmolality were achieved at least for 1 month. The possible use of this method for other peptides and its application in small or immature laboratory animals and in fetuses is emphasized.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
27 articles.
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