In-vivo hypocalcaemic, hypophosphataemic and hyperlipaemic activities in the common peptide sequence of adrenocorticotrophin, melanocyte-stimulating hormone and lipotrophin

Abstract

A heptapeptide solution in acetate buffer (pH = 4, 150 μg/kg) of the amino acid sequence common to ACTH, α- and β-MSH and lipotrophin, when injected intravenously into rabbits produced an increase in total lipids, cholesterol and free fatty acids after 1 h and a decrease in plasma calcium and phosphate after 2 h. No significant modification in the amount of creatinine, uric acid, urea, total proteins, CO2, Cl−, K+ or Na+ was observed.