Author:
POYSER N. L.,HORTON E. W.
Abstract
SUMMARY
Five guinea-pigs actively immunized against a prostaglandin F2α(PGF2α)–bovine serum albumin conjugate showed elongated oestrous cycles. During these, corpora lutea were maintained in a functional secretory state as indicated by plasma progesterone levels. The results are compatible with the view that the PGF2α antibodies neutralized the PGF2α released from the uterus and thus prevented its normal luteolytic effect. Similar patterns of progesterone secretion were observed in two hysterectomized animals and in two animals with intra-uterine implants of indomethacin.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
21 articles.
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5. Local luteolytic effect of prostaglandin F2α in the human corpus luteum**Supported by grant 2873 from the Swedish Medical Research Council, the Swedish Society of Medical Sciences, Stockholm Sweden, the Medical Faculty, University of Göteborg and the Göteborg Medical Society, Göteborg, Sweden.††Presented at the 7th World Congress on Human Reproduction, Helsinki, Finland, June 27, 1990.;Fertility and Sterility;1991-12