SERUM FOLLICLE-STIMULATING HORMONE, LUTEINIZING HORMONE AND PROGESTERONE CONCENTRATIONS IN PSEUDOPREGNANT RATS TREATED WITH MEDROXYPROGESTERONE ACETATE

Abstract

SUMMARY Pseudopregnant rats were treated early in pseudopregnancy with 1 or 10 mg medroxyprogesterone acetate (MPA). Serum FSH, LH and progesterone concentrations were determined on days 2–20 of pseudopregnancy in treated and control rats. The mean duration of pseudopregnancy was 13·5 days in the control animals, but when animals were treated with 1 mg MPA a dioestrous period of 21·4 days was observed. A period with leucocytic vaginal smears of at least 2 months was observed after treatment with 10 mg MPA. Injection with MPA on day 3 of pseudopregnancy did not affect the serum FSH concentrations during the subsequent days. The progesterone pattern was alike in the three groups of animals, i.e. the duration of the activity of the corpora lutea was similar in all groups. However, 10 mg MPA slightly lowered progesterone concentrations on days 4–8 of pseudopregnancy. In the saline-treated rats, LH concentrations decreased from days 2–5, and remained low until they increased after day 11 of pseudopregnancy. This increase was delayed until day 20 in the animals treated with 1 mg MPA, and was not observed in the animals treated with 10 mg MPA. It is argued that the increase of LH concentration at the end of pseudopregnancy is not instrumental in the decrease of peripheral progesterone concentration but rather that the decrease in the progesterone concentration leads to the increase in the LH concentration.