Author:
MILLER B. G.,EMMENS C. W.
Abstract
SUMMARY
The pattern of changes in levels of uridine incorporation into uterine and vaginal RNA at different times after the commencement of daily injections of several dose combinations of oestradiol and progesterone has been determined. Progesterone does not antagonize the response to oestradiol in the uterus and vagina at 16 hr., but in the uterus augments the effects of lower doses of oestradiol. At 48 hr., progesterone eliminates the response to oestradiol in the vagina. The interaction in the uterus is more complex. At 47 hr., or later, relatively high levels of uridine incorporation into uterine RNA are maintained by the administration of either oestradiol alone, at doses of 27 ng. or more; or by oestradiol and progesterone together, at doses of about 6 ng. and 0·33 mg. respectively. In mice receiving intraluminal peanut oil as a decidual stimulus the sensitivity of the uterus to deciduoma formation is not well correlated with its ability to incorporate uridine into RNA.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
27 articles.
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