THE RELATIVE POTENCIES OF OESTRIOL, OESTRADIOL AND OESTRONE ON THE UTERUS AND VAGINA OF THE MOUSE

Abstract

SUMMARY The effects of oestriol, oestradiol and oestrone on the uterus and vagina of the mouse have been investigated, by measuring changes in the incorporation of tritiated uridine into RNA, and in wet and dry organ weight. The time course of the uridine response to a single injection of oestriol differs markedly from that seen with single injections of oestradiol and oestrone. Oestriol has only a weak uterotrophic action in tests employing daily oestrogen injections, but when administered every 4 hr. in small doses it elicits as much growth in both organs as does oestradiol. The relative capacities of oestriol and oestradiol to sensitize the uterus to the induction of deciduomata by peanut oil are contrasted.