Abstract
SUMMARY
In order to determine the probable availability of protein-bound cortisol to the tissues, the establishment of equilibrium between transcortin-bound [3H]cortisol and unbound [14C]cortisol in plasma has been followed using Sephadex gel filtration. Association of cortisol with transcortin was rapid; dissociation of the steroid-protein complex was comparatively slow; when the binding-sites were nearly saturated the half-dissociation times of [3H]cortisol were 25 min. at 4°, 1 min. at 22° and about 10 sec. at 37°.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
50 articles.
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