INFLUENCE OF OESTRADIOL ON CITRATE ACCUMULATION IN THE UTERUS AND BLOOD OF FLUOROACETATE-TREATED RATS

Abstract

SUMMARY The uterus, ovary and kidney of rats treated with fluoroacetate accumulated large quantities of citrate. It was inferred that a citric acid cycle operates in the uterus, ovary and kidney of castrated and normal rats. After the administration of oestrogen, citrate accumulation 3 hr. after fluoroacetate was slightly increased at 24 hr., but much reduced 96 hr. after the oestrogen had been injected. It is postulated that during the first 24 hr. after oestrogen injection, oxidative respiration by way of the citric acid cycle takes place. Thereafter alternative metabolic pathways may predominate, the citric acid cycle in the uterus being depressed.